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台湾一起由商业食品引起的A型肉毒中毒暴发:临床与流行病学调查

Outbreak of type A botulism caused by a commercial food product in Taiwan: clinical and epidemiological investigations.

作者信息

Tsai S J, Chang Y C, Wang J D, Chou J H

机构信息

Department of Internal Medicine, Chung Shan Medical and Dental College, Taichung, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1990 Jul;46(1):43-8.

PMID:2176923
Abstract

In late September 1986, we found 7 patients from a printing factory in Chang-Hwa city who developed an endemic disease manifested by general malaise, ptosis, double vision, dysarthria, dysphagia, and proximal limb weakness. After clinical, epidemiological, microbiological, and toxicological investigations, an outbreak of botulism was confirmed 2 weeks later, Commercially canned peanuts made by an unlicensed cannery were identified as the vehicle of botulinum toxin transmission. Antitoxin was given to 2 patients who needed ventilator support. One of the 7 victims died from medical complications and the remaining 6 patients recovered. Several administrative problems exposed in this outbreak were the poor governmental supervision of canned food, the inadequate quantities of "orphan drugs" stored in this country, the inefficient system for recalling the problem products, and the delayed broadcasting of warnings to the public. Since commercially processed food is increasingly popular with modernization, the possibility of future botulism outbreaks should not be overlooked.

摘要

1986年9月下旬,我们在彰化市一家印刷厂发现7名患者,他们患上一种地方病,症状包括全身不适、眼睑下垂、复视、构音障碍、吞咽困难及近端肢体无力。经过临床、流行病学、微生物学及毒理学调查,两周后证实这是一起肉毒中毒事件。一家无证罐头厂生产的商业罐装花生被确定为肉毒杆菌毒素传播媒介。对2名需要呼吸机支持的患者使用了抗毒素。7名受害者中有1人死于并发症,其余6名患者康复。此次疫情暴露出一些管理问题,包括政府对罐头食品监管不力、国内“孤儿药”储备量不足、问题产品召回体系效率低下以及向公众发布警告延迟。由于商业加工食品随着现代化进程越来越受欢迎,未来肉毒中毒疫情爆发的可能性不容小觑。

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