Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique et Université de Strasbourg, Département Nociception et Douleur, Strasbourg, France.
Physiol Behav. 2011 Oct 24;104(5):694-701. doi: 10.1016/j.physbeh.2011.07.004. Epub 2011 Jul 13.
Evaluation of pain is a critical issue in human pathologies but also in animal experimentation. In human studies there is growing evidence that cardiovascular outputs such as heart rate variability (HRV) might be of interest to detect and measure pain expression. Indeed, systems controlling cardiovascular function are closely coupled to the perception of pain. To demonstrate the interest of HRV, we have combined radiotelemetry and remote-controlled nociceptive tests in rats submitted to various situations of acute and persistent inflammatory pain. We found the Poincaré plot descriptor SD1 and pNN18 to represent robust indicators of pain, especially in the case of persistent inflammatory states. Further studies will be performed in order to understand by which mechanisms pain-related increases in HRV are produced and if these descriptors can be used for other persistent pain states.
疼痛评估是人类病理学以及动物实验研究中的一个关键问题。越来越多的证据表明，心率变异性（HRV）等心血管输出可能有助于发现和测量疼痛的表达。事实上，控制心血管功能的系统与疼痛的感知密切相关。为了证明 HRV 的意义，我们结合无线电遥测和远程控制的伤害性测试，对大鼠进行了各种急性和持续性炎症疼痛情况的实验。我们发现 Poincaré plot 描述符 SD1 和 pNN18 是疼痛的可靠指标，特别是在持续性炎症状态下。进一步的研究将旨在了解与疼痛相关的 HRV 增加的产生机制，以及这些描述符是否可以用于其他持续性疼痛状态。
