通用的与特定疾病的健康相关生活质量是否相关？以硫芥所致慢性肺病为例。
Are generic and disease-specific health related quality of life correlated? The case of chronic lung disease due to sulfur mustard.
作者信息
Assari Shervin, Lankarani Maryam Moghani, Montazeri Ali, Soroush Mohammad Reza, Mousavi Batol
机构信息
Psychiatry Department, Medicine and Health Promotion Institute, Tehran Iran.
出版信息
J Res Med Sci. 2009 Sep;14(5):285-90.
BACKGROUND
The aim of this study was to investigate the association between the two most commonly used generic and disease specific health-related quality of life (HRQoL) measures in patients with chronic lung disease due to SM: Medical Outcomes Study Short Form 36-Item (SF-36) and St George's Respiratory Questionnaire (SGRQ).
METHODS
This is a secondary analysis of Iranian Chemical Warfare Victims Health Assessment Study (ICWVHAS) during October 2007 in Isfahan, Iran. In that survey, conducted in an outpatient setting, 292 patients with chronic lung disease due to SM were selected from all provinces in Iran. The total score and sub scores of correlations of SGRQ and SF-36 were assessed. Correlation of quality-of-life scores were evaluated using Pearson's coefficient.
RESULTS
Samples were 276 patients who were selected for our analysis. No significant correlation was found between the total score or sub scores of SF-36 and the total score or sub scores of SGRQ (p > 0.05).
CONCLUSIONS
In patients with chronic lung disease due to SM, the SF-36 and SGRQ assess different aspects of HRQoL. Therefore applying both of them together, at least in the research setting is suggested.
背景
本研究旨在调查在因沙林毒气导致的慢性肺病患者中，两种最常用的通用型和疾病特异性健康相关生活质量（HRQoL）测量工具之间的关联：医学结局研究简明健康调查问卷（SF-36）和圣乔治呼吸问卷（SGRQ）。
方法
这是对2007年10月在伊朗伊斯法罕进行的伊朗化学战受害者健康评估研究（ICWVHAS）的二次分析。在那次门诊环境中的调查中，从伊朗所有省份选取了292名因沙林毒气导致的慢性肺病患者。评估了SGRQ和SF-36的总分及各分项得分之间的相关性。使用皮尔逊系数评估生活质量得分的相关性。
结果
选取了276名患者进行我们的分析。SF-36的总分或分项得分与SGRQ的总分或分项得分之间未发现显著相关性（p>0.05）。
结论
在因沙林毒气导致的慢性肺病患者中，SF-36和SGRQ评估的是HRQoL的不同方面。因此，建议至少在研究环境中将两者一起应用。
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