Ståhl Elisabeth, Lindberg Anne, Jansson Sven-Arne, Rönmark Eva, Svensson Klas, Andersson Fredrik, Löfdahl Claes-Göran, Lundbäck Bo
Department of Respiratory Medicine and Allergology, University Hospital, SE-221 85 Lund, Sweden.
Health Qual Life Outcomes. 2005 Sep 9;3:56. doi: 10.1186/1477-7525-3-56.
The aim of this study was to evaluate the association between health-related quality of life (HRQL) and disease severity using lung function measures.
A survey was performed in subjects with COPD in Sweden. 168 subjects (70 women, mean age 64.3 years) completed the generic HRQL questionnaire, the Short Form 36 (SF-36), the disease-specific HRQL questionnaire; the St George's Respiratory Questionnaire (SGRQ), and the utility measure, the EQ-5D. The subjects were divided into four severity groups according to FEV1 per cent of predicted normal using two clinical guidelines: GOLD and BTS. Age, gender, smoking status and socio-economic group were regarded as confounders.
The COPD severity grades affected the SGRQ Total scores, varying from 25 to 53 (GOLD p = 0.0005) and from 25 to 45 (BTS p = 0.0023). The scores for SF-36 Physical were significantly associated with COPD severity (GOLD p = 0.0059, BTS p = 0.032). No significant association were noticed for the SF-36, Mental Component Summary scores and COPD severity. Scores for EQ-5D VAS varied from 73 to 37 (GOLD I-IV p = 0.0001) and from 73 to 50 (BTS 0-III p = 0.0007). The SGRQ Total score was significant between age groups (p = 0.0047). No significant differences in HRQL with regard to gender, smoking status or socio-economic group were noticed.
The results show that HRQL in COPD deteriorates with disease severity and with age. These data show a relationship between HRQL and disease severity obtained by lung function.
本研究旨在通过肺功能指标评估健康相关生活质量（HRQL）与疾病严重程度之间的关联。
在瑞典对慢性阻塞性肺疾病（COPD）患者进行了一项调查。168名受试者（70名女性，平均年龄64.3岁）完成了通用HRQL问卷、简明健康调查问卷（SF-36）、疾病特异性HRQL问卷；圣乔治呼吸问卷（SGRQ）以及效用测量工具EQ-5D。根据两种临床指南（全球慢性阻塞性肺疾病倡议（GOLD）和英国胸科学会（BTS）），按照预测正常FEV1百分比将受试者分为四个严重程度组。年龄、性别、吸烟状况和社会经济群体被视为混杂因素。
COPD严重程度等级影响SGRQ总分，范围从25至53（GOLD，p = 0.0005）以及从25至45（BTS，p = 0.0023）。SF-36身体维度得分与COPD严重程度显著相关（GOLD，p = 0.0059；BTS，p = 0.032）。未发现SF-36心理维度总分得分与COPD严重程度之间存在显著关联。EQ-5D视觉模拟量表（VAS）得分范围从73至37（GOLD I-IV，p = 0.0001）以及从73至50（BTS 0-III，p = 0.0007）。SGRQ总分在年龄组之间存在显著差异（p = 0.0047）。未发现HRQL在性别、吸烟状况或社会经济群体方面存在显著差异。
结果表明，COPD患者的HRQL随疾病严重程度和年龄而恶化。这些数据显示了HRQL与通过肺功能获得的疾病严重程度之间的关系。
