三氟甲基磺酸酯促进的铜介导的芳基硼酸三氟甲基化反应。

Copper-mediated trifluoromethylation of arylboronic acids by trifluoromethyl sulfonium salts.

机构信息

Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.

出版信息

Chem Commun (Camb). 2011 Sep 7;47(33):9516-8. doi: 10.1039/c1cc13460d. Epub 2011 Jul 19.

DOI:10.1039/c1cc13460d

PMID:21773611

Abstract

The ligand-free trifluoromethylation of arylboronic acids with a Ph(2)SCF(3)OTf/Cu(0) system has been carefully investigated. Aryl-, alkenyl- and heteroarylboronic acids with a variety of functional groups were suitable substrates for this reaction. It is suggested that a CuCF(3) species is formed under the reaction conditions.

摘要

芳基硼酸与Ph(2)SCF(3)OTf/Cu(0)体系的无配体三氟甲基化反应得到了仔细研究。具有各种官能团的芳基、烯基和杂芳基硼酸都是该反应的合适底物。反应条件下形成了 CuCF(3)物种。