GSI Helmholtzzentrum für Schwerionenforschung, Planckstr. 1, 64291 Darmstadt, Germany.
Phys Med Biol. 2011 Aug 21;56(16):R113-44. doi: 10.1088/0031-9155/56/16/R01. Epub 2011 Jul 20.
Charged particle beam radiotherapy requires dedicated measures to compensate for the dosimetric influence of inter- and intra-fractional target motion. Independent of the delivery technique, these measures have to incorporate the strong influence of the radiological depth on the delivered dose. For scanned beam delivery, interference effects of target motion and scanned beam can further cause under-dosage of the clinical target volume despite using margins. Within the scope of this review, published data with respect to motion management in scattered as well as scanned beam treatment delivery will be summarized. Based on a section covering the dosimetric impact of organ motion, motion management during treatment planning, patient positioning, treatment delivery and treatment validation will be summarized. For scattered beam delivery, the concepts and data are often based on clinical usage since treatment of moving tumors has been performed for several years. In the field of scanned beam delivery, the report focuses on the results of research on countermeasures of the interference effect. Clinical application of these techniques can be expected in the near future.
带电粒子束放射治疗需要采取专门的措施来补偿靶区内外运动的剂量学影响。无论采用何种治疗技术，这些措施都必须考虑到辐射深度对所给予剂量的强烈影响。对于扫描束递送，尽管使用了边缘，但靶区运动和扫描束的干涉效应仍可能导致临床靶区体积的剂量不足。在本次综述的范围内，将总结关于散束和扫描束治疗递送中运动管理的已发表数据。基于涵盖器官运动剂量学影响的部分，将总结治疗计划、患者定位、治疗递送和治疗验证过程中的运动管理。对于散束递送，概念和数据通常基于临床应用，因为多年来一直在对移动肿瘤进行治疗。在扫描束递送领域，本报告重点介绍了针对干涉效应的对策的研究结果。这些技术的临床应用有望在不久的将来实现。
