Li Z S
Guangxi Medical College, Nanning.
Zhonghua Bing Li Xue Za Zhi. 1990 Sep;19(3):215-7.
Nuclear DNA content of malignant cells was measured by OPTON type III microspectrophotometry in 19 cases of hepatocellular carcinoma (HCC), as well as cells from the paraneoplastic tissue. The mean DNA value increased significantly from non liver cell dysplasia (LCD), LCD to HCC (P less than 0.05-0.01). In histograms, non-LCD hepatocyte showed a single-peak type located at 2C. HCC showed lower multi-peaks which migrated to 4C and spread widely with more aneuploid (greater than 5C) cells. The histograms of LCD were between non-LCD and HCC, and there were also some aneuploids in LCD. These results suggest that LCD is a group of proliferating cells, and those with relatively high ratio of aneuploid cells might be premalignant.
采用OPTON III型显微分光光度法对19例肝细胞癌（HCC）及其癌旁组织细胞的核DNA含量进行了测定。DNA均值从非肝细胞发育异常（LCD）、LCD到HCC显著升高（P＜0.05 - 0.01）。在直方图中，非LCD肝细胞呈现位于2C的单峰型。HCC呈现较低的多峰，向4C迁移并广泛分布，非整倍体（＞5C）细胞更多。LCD的直方图介于非LCD和HCC之间，LCD中也存在一些非整倍体细胞。这些结果提示，LCD是一组增殖细胞，非整倍体细胞比例相对较高者可能为癌前病变。
