[Analysis of DNA content of cells from liver cell dysplasia and hepatocellular carcinoma].

Nuclear DNA content of malignant cells was measured by OPTON type III microspectrophotometry in 19 cases of hepatocellular carcinoma (HCC), as well as cells from the paraneoplastic tissue. The mean DNA value increased significantly from non liver cell dysplasia (LCD), LCD to HCC (P less than 0.05-0.01). In histograms, non-LCD hepatocyte showed a single-peak type located at 2C. HCC showed lower multi-peaks which migrated to 4C and spread widely with more aneuploid (greater than 5C) cells. The histograms of LCD were between non-LCD and HCC, and there were also some aneuploids in LCD. These results suggest that LCD is a group of proliferating cells, and those with relatively high ratio of aneuploid cells might be premalignant.