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本文引用的文献

1
Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children.脂质负荷巨噬细胞指数并非儿童胃食管反流相关呼吸道疾病的一个指标。
Pediatrics. 2008 Apr;121(4):e879-84. doi: 10.1542/peds.2007-0723. Epub 2008 Mar 24.
2
Pathogenic colonization of the stomach in enterally fed elderly patients: Comparing percutaneous endoscopic gastrostomy with nasogastric tube.肠内喂养老年患者的胃致病性定植：经皮内镜下胃造口术与鼻胃管的比较
J Am Geriatr Soc. 2006 Dec;54(12):1905-8. doi: 10.1111/j.1532-5415.2006.00964.x.
3
Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.使用胃酸抑制剂进行治疗会增加儿童患急性肠胃炎和社区获得性肺炎的风险。
Pediatrics. 2006 May;117(5):e817-20. doi: 10.1542/peds.2005-1655.
4
The importance of multichannel intraluminal impedance in the evaluation of children with persistent respiratory symptoms.多通道腔内阻抗在评估持续性呼吸道症状儿童中的重要性。
Am J Gastroenterol. 2004 Dec;99(12):2452-8. doi: 10.1111/j.1572-0241.2004.40268.x.
5
Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease.胃蛋白酶和碳酸酐酶同工酶III作为喉咽反流病的诊断标志物。
Laryngoscope. 2004 Dec;114(12):2129-34. doi: 10.1097/01.mlg.0000149445.07146.03.
6
Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.社区获得性肺炎的风险与胃酸抑制药物的使用
JAMA. 2004 Oct 27;292(16):1955-60. doi: 10.1001/jama.292.16.1955.
7
Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers.24小时动态同步阻抗和pH监测：60名健康志愿者正常值的多中心报告。
Am J Gastroenterol. 2004 Jun;99(6):1037-43. doi: 10.1111/j.1572-0241.2004.04172.x.
8
Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease.患有反流疾病的早产和足月婴儿胃食管反流的机制。
Gut. 2002 Oct;51(4):475-9. doi: 10.1136/gut.51.4.475.
9
Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition.婴幼儿胃食管反流评估与治疗指南：北美儿科胃肠病学与营养学会建议
J Pediatr Gastroenterol Nutr. 2001;32 Suppl 2:S1-31. doi: 10.1097/00005176-200100002-00001.
10
Suppression of gastric acid secretion in patients with gastroesophageal reflux disease results in gastric bacterial overgrowth and deconjugation of bile acids.胃食管反流病患者胃酸分泌受抑制会导致胃内细菌过度生长以及胆汁酸去结合。
J Gastrointest Surg. 2000 Jan-Feb;4(1):50-4. doi: 10.1016/s1091-255x(00)80032-3.

非酸性反流和呼吸障碍患儿支气管肺泡灌洗培养阳性率较高。

Higher rate of bronchoalveolar lavage culture positivity in children with nonacid reflux and respiratory disorders.

机构信息

Center for Motility and Functional Gastrointestinal Disorders, Children's Hospital Boston, Boston, MA 02115, USA.

出版信息

J Pediatr. 2011 Sep;159(3):504-6. doi: 10.1016/j.jpeds.2011.05.021. Epub 2011 Jul 21.

DOI:10.1016/j.jpeds.2011.05.021
PMID:21777922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3157561/
Abstract

The aim of the study was to determine if children with chronic cough or wheezing and with more full-column, nonacid reflux have a higher likelihood of a positive bronchoalveolar lavage fluid culture. In a prospective study of 46 children with cough who were undergoing endoscopy, multichannel intraluminal impedance testing, and bronchoscopy, we found that patients who had a positive culture had significantly more full-column, nonacid gastroesophageal reflux than those who had a negative culture.

摘要

本研究旨在确定是否患有慢性咳嗽或喘息且存在更多全柱、非酸性反流的儿童，其支气管肺泡灌洗液培养阳性的可能性更高。在一项对 46 名接受内镜检查、多通道腔内阻抗测试和支气管镜检查的咳嗽患儿进行的前瞻性研究中，我们发现，培养阳性的患者全柱、非酸性胃食管反流明显多于培养阴性的患者。