Vajpayee Vaishali, Song Young Ho, Yang Yoon Jung, Kang Se Chan, Kim Hyunuk, Kim In Su, Wang Ming, Stang Peter J, Chi Ki-Whan
Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea.
Organometallics. 2011 Jun 27;30(12):3242-3245. doi: 10.1021/om200294x.
The synthesis of new 2+2 metalla-rectangles via coordination driven self-assembly of octahedral Ru(II) based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin.
本文描述了通过基于八面体钌（II）的受体与酰胺供体的配位驱动自组装合成新型2+2金属矩形。为了评估它们的体外细胞毒性特性，对各种人类癌细胞系进行了初步生物学测定，我们的结果表明，在SK-hep-1和HCT-15细胞系中，化合物3的细胞毒性水平与参考药物顺铂相当，甚至更高。
