基于钌的分子矩形的配位驱动自组装：合成、表征、光物理和抗癌活性研究。
Coordination-driven self-assembly of ruthenium-based molecular-rectangles: synthesis, characterization, photo-physical and anticancer potency studies.
机构信息
Department of Chemistry, University of Ulsan, Ulsan, Republic of Korea.
出版信息
Dalton Trans. 2012 Mar 14;41(10):3046-52. doi: 10.1039/c2dt11811d. Epub 2012 Jan 26.
Abstract
A suite of eight cationic, tetra-metallic molecular rectangles (1-8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1-A4) with one of two dipyridyl ligands (D1, D2). The high-yielding (84-92%) rectangles were characterized by (1)H NMR and HR-ESI-MS to support their structural assignments. The molecular structure of 5 was determined by single crystal X-ray analysis, which indicated that two D2 ligands bridge two A1 acceptors to form a rectangular construct. The photophysical properties of these metalla-rectangles and their molecular precursors were also investigated, as well as an MTT assay to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents, cisplatin and doxorubicin. MTT assays were conducted using SK-hep-1 (liver cancer) and HCT-15 (colon cancer) human cancer cell lines. Compounds 3, 4, 7 and 8 showed significant activity, with IC(50) values comparable to those of cisplatin and doxorubicin.
摘要
生成了一套八个阳离子、四金属分子矩形（1-8），通过使用四个二羧酸桥接芳烃-Ru 前体（A1-A4）与两个二吡啶配体（D1，D2）之一的配位驱动自组装来生成。高产率（84-92%）的矩形通过（1）H NMR 和 HR-ESI-MS 进行了表征，以支持其结构分配。5 的分子结构通过单晶 X 射线分析确定，表明两个 D2 配体桥接两个 A1 受体形成矩形结构。还研究了这些金属矩形及其分子前体的光物理性质，以及体外细胞毒性评估与两种化疗药物顺铂和阿霉素的 MTT 测定。MTT 测定使用 SK-hep-1（肝癌）和 HCT-15（结肠癌）人癌细胞系进行。化合物 3、4、7 和 8 表现出显著的活性，IC（50）值与顺铂和阿霉素相当。
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