Mouzakis John A, Liu Stephanie, Cohen George
J Clin Aesthet Dermatol. 2011 Jun;4(6):41-4.
Vitiligo is a common depigmenting condition that carries a high psychosocial morbidity. Many of the current topical and light therapies aid in repigmentation but require extensive treatment periods and carry unwanted side effects. The excimer laser is a newer treatment option that can induce repigmentation in an abbreviated time frame without global exposure to radiation. This case series provides further evidence to support the use of excimer laser in treating vitiligo especially of the face.
Patients with extensive facial depigmentation were treated with excimer laser twice weekly and calcipotriene daily until they developed significant repigmentation.
Evaluation and treatment was performed at the Veterans Affairs outpatient dermatology clinic in Tampa, Florida.
Three patients with Fitzpatrick skin types IV to VI were selected. These patients had failed a variety of topical treatments including steroids and calcipotriene, but were light naïve prior to beginning the study.
The primary outcome measure employed was percent repigmentation by visual estimation. The average dose of radiation, number of treatments, and weeks of therapy were also recorded.
All three patients experienced greater than 75 percent repigmentation of their facial vitiligo over a treatment course from 10 to 20 weeks.
The excimer laser is a viable treatment for vitiligo and may yield results more expeditiously than other commonly utilized therapies. The rapid response may be correlated with skin type, but a more extensive study needs to be undertaken to further evaluate this correlation.
白癜风是一种常见的色素脱失性疾病，具有较高的心理社会发病率。目前许多局部和光疗有助于色素再生，但需要较长的治疗周期且伴有不良副作用。准分子激光是一种较新的治疗选择，可在较短时间内诱导色素再生，且不会使全身暴露于辐射中。本病例系列提供了进一步的证据，支持使用准分子激光治疗白癜风，尤其是面部白癜风。
对面部广泛色素脱失的患者，每周用准分子激光治疗两次，每天外用卡泊三醇，直至出现明显的色素再生。
在佛罗里达州坦帕市的退伍军人事务部门诊皮肤科诊所进行评估和治疗。
选择了3例Fitzpatrick皮肤类型为IV至VI型的患者。这些患者曾尝试过多种局部治疗，包括类固醇和卡泊三醇，但在开始本研究之前未接受过光疗。
主要的观察指标是通过视觉估计色素再生的百分比。还记录了平均辐射剂量、治疗次数和治疗周数。
所有3例患者在10至20周的治疗过程中，面部白癜风的色素再生均超过75%。
准分子激光是治疗白癜风的一种可行方法，可能比其他常用疗法更快地产生效果。快速反应可能与皮肤类型有关，但需要进行更广泛的研究以进一步评估这种相关性。
