Department of Pediatrics and Institute of Allergy, Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Lung. 2011 Oct;189(5):417-23. doi: 10.1007/s00408-011-9312-5. Epub 2011 Jul 22.
Asthma and atopy have a complex background that may result from the interaction of genes and the environment. Interleukin (IL)-10 is known to play various roles in immune-regulating and anti-inflammatory responses. The aim of this study was to evaluate the possible effect of the IL-10 promoter polymorphisms on susceptibility to childhood asthma. We recruited 333 patients with atopic asthma, 55 with nonatopic asthma, and 248 normal controls. We performed a genetic association study of three genetic polymorphisms (IL-10 -1082A>G, IL-10 -819T>C, and IL-10 -592A>C) of the IL-10 promoter. There was no difference between atopic asthma, nonatopic asthma, and normal controls with respect to allele, genotype, or haplotype frequencies of these IL-10 polymorphisms. However, the -1082A>G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) and the -819T>C, -592A>C, and ATA and ACC haplotypes were also shown to be related to serum eosinophil cationic protein (ECP). Our results suggest that the polymorphisms within the IL-10 promoter may have a disease-modifying effect in the asthmatic airway.
哮喘和过敏症具有复杂的背景，可能是由基因和环境相互作用导致的。白细胞介素（IL）-10 已知在免疫调节和抗炎反应中发挥多种作用。本研究旨在评估 IL-10 启动子多态性对儿童哮喘易感性的可能影响。我们招募了 333 名特应性哮喘患者、55 名非特应性哮喘患者和 248 名正常对照。我们对 IL-10 启动子的三个遗传多态性（IL-10 -1082A>G、IL-10 -819T>C 和 IL-10 -592A>C）进行了遗传关联研究。在这些 IL-10 多态性的等位基因、基因型或单倍型频率方面，特应性哮喘、非特应性哮喘和正常对照组之间没有差异。然而，IL-10 启动子基因中的-1082A>G 多态性和 ATA 单倍型与气道高反应性（AHR）相关，-819T>C、-592A>C 和 ATA 和 ACC 单倍型也与血清嗜酸性粒细胞阳离子蛋白（ECP）相关。我们的结果表明，IL-10 启动子内的多态性可能对哮喘气道具有疾病修饰作用。
