浓缩生长因子中生长因子、CD34 阳性细胞和纤维蛋白网络分析。
Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction.
机构信息
Department of Biomedical Sciences and Biotechnologies, Division of Human Anatomy, University of Brescia, V.le Europa 11, 25123 Brescia, Italy.
出版信息
Microsc Res Tech. 2011 Aug;74(8):772-7. doi: 10.1002/jemt.20968.
An interesting clinical option for optimizing healing tissue is the use of platelet concentrate. Platelets contain high quantities of growth factors, among these TGF-β1 and VEGF, which are known to be implicated in tissue regeneration. CGF is produced by processing blood samples with a special centrifuge device; three layers are formed: top acellular plasma (PPP), middle CGF and bottom red blood cells (RBC) layers. Given that to date there are no data concerning the biological characteristic of CGF, the aim of this study was to evaluate the presence of TGF-β1 and VEGF in CGF and also in PPP and RBC layers. In addition, since circulating stem cells are recruited from blood to injured tissue for healing we also evaluated the presence of CD34 positive cells. Our data show the presence of TGF-β1 and VEGF in CGF and RBC layers. In addition, we show CD34 positive cells in CGF.
一种优化组织愈合的有趣的临床选择是使用血小板浓缩物。血小板含有大量的生长因子，其中 TGF-β1 和 VEGF 已知与组织再生有关。CGF 通过使用特殊的离心机设备处理血液样本产生;形成了三层：顶部无细胞血浆 (PPP)、中间 CGF 和底部红细胞 (RBC) 层。鉴于迄今为止尚无关于 CGF 生物学特性的数据，本研究旨在评估 TGF-β1 和 VEGF 在 CGF 以及 PPP 和 RBC 层中的存在。此外，由于循环干细胞从血液募集到受伤组织进行愈合，我们还评估了 CD34 阳性细胞的存在。我们的数据显示 TGF-β1 和 VEGF 存在于 CGF 和 RBC 层中。此外，我们还在 CGF 中显示了 CD34 阳性细胞。
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