Hilborn Jons
Department of Materials Chemistry, Uppsala University, Uppsala 75121, Sweden.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Nov-Dec;3(6):589-606. doi: 10.1002/wnan.91. Epub 2011 Jul 21.
The desire to reduce healthcare costs while improving outcomes drives minimally invasive methods to replacing traditional surgical procedures. Various treatments that would previously have needed open-type surgeries can be carried out using endoscopes, catheters, and needles. These advantages have become especially obvious for tissue engineering and regenerative medicine with in vivo gel injectable nanomaterials. In this review, the state of the art in this rapidly developing field is given. This is done by contrasting functional evaluation in vitro with in vivo followed by describing (1) synthetic materials, (2) the body's own polymers, (3) polymers in nature, (4) self-assembled peptides, and (5) new innovations and combinations. With increased understanding of the relationship between material characteristics and the outcome in vivo more rational design criteria are emerging.
在改善医疗结果的同时降低医疗成本的需求推动了微创方法取代传统外科手术。以前需要开放式手术的各种治疗现在可以使用内窥镜、导管和针头来进行。对于体内可注射凝胶纳米材料的组织工程和再生医学来说，这些优势尤为明显。在这篇综述中，介绍了这个快速发展领域的最新进展。通过对比体外和体内的功能评估来实现这一点，随后描述了（1）合成材料，（2）人体自身的聚合物，（3）天然聚合物，（4）自组装肽，以及（5）新的创新和组合。随着对材料特性与体内结果之间关系的理解不断加深，越来越合理的设计标准正在出现。
