Toxicity and sphinganine levels are correlated in rats fed fumonisin B(1) (FB(1)) or hydrolyzed FB(1).

Nixtamalization of Fusarium moniliforme culture material reduced, but did not eliminate, its toxicity to rats. Liver and kidney sphinganine concentration and sphinganine to sphingosine ratio of the animals fed diets containing water extracted (8 ppm fumonisin B(1) (FB(1))), nixtamalized (58 ppm hydrolyzed FB(1)), or unprocessed culture material (71 ppm FB(1)) were increased compared to those fed a diet lacking detectable fumonisins. Increases were generally correlated with the severity of hepatic and renal lesions and were highly correlated (P<0.0001) with body weight effects and serum chemical indications of hepatotoxicity. The findings are further evidence that inhibition of the enzyme ceramide synthase may be a key event in fumonisin toxigenesis.