Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain.
J Cataract Refract Surg. 2011 Aug;37(8):1481-7. doi: 10.1016/j.jcrs.2011.03.036.
To evaluate and compare the tear-film dynamics in normal eyes and in eyes with mild dry-eye symptoms using a new noninvasive optical method based on a double-pass instrument.
Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Evaluation of diagnostic test or technology.
Dynamic recording of double-pass retinal images during unforced tear-film breakup was performed in eyes with mild dry-eye symptoms (study group) and in an asymptomatic control group. Series of consecutive retinal images were recorded every 0.5 seconds while the patient avoided blinking. Measurements were performed under low-light conditions to naturally increase pupil diameter and maximize the method's sensitivity. Additional clinical tests were performed for comparison and included tear breakup time (TBUT), Schirmer I tests, and a normalized questionnaire (McMonnies). From the retinal images, a quality metric, the intensity distribution index, was calculated. An objective TBUT value was estimated in each eye when the intensity distribution index surpassed a defined threshold value compared with the initial baseline.
The study group comprised 20 eyes and the control group, 18 eyes. Symptomatic dry eyes had a typical exponential increase in the intensity distribution index with time. The objective TBUT values in the study group were comparable to the clinical TBUT estimates.
The new objective optical method to evaluate the quality and stability of the tear film was sensitive in detecting mild symptoms of dry eye and differentiating from normal cases. The procedure may allow early detection and follow-up of patients' tear film-related complaints.
使用一种基于双通道仪器的新型非侵入性光学方法评估和比较正常眼与轻度干眼症状眼的泪膜动力学。
西班牙穆尔西亚市阿利坎特大学医院。
诊断测试或技术评估。
在轻度干眼症状眼（研究组）和无症状对照组中，进行非强制泪膜破裂时双通视网膜图像的动态记录。在患者避免眨眼的情况下，每 0.5 秒记录一系列连续的视网膜图像。在低光照条件下进行测量，以自然增加瞳孔直径并最大程度提高该方法的灵敏度。进行了其他临床测试进行比较，包括泪膜破裂时间（TBUT）、Schirmer I 测试和标准化问卷（McMonnies）。从视网膜图像中计算出一个质量指标，即强度分布指数。当强度分布指数超过与初始基线相比定义的阈值时，估计每只眼中的客观 TBUT 值。
研究组包括 20 只眼，对照组包括 18 只眼。有症状的干眼的强度分布指数随时间呈典型的指数增长。研究组的客观 TBUT 值与临床 TBUT 估计值相当。
评估泪膜质量和稳定性的新型客观光学方法对轻度干眼症状敏感，可与正常情况区分开来。该程序可能允许早期发现和跟踪患者的与泪膜相关的投诉。
