Ishimaru Y, Nakano H, Oseto M, Yamashita Y, Kobayashi N, Urasawa S
Ishimaru Pediatric Clinic, Matsuyama, Japan.
Acta Paediatr Jpn. 1990 Oct;32(5):523-9. doi: 10.1111/j.1442-200x.1990.tb00874.x.
We recently found many cases of gastroenteritis involving older children and sometimes other members of their families. We suspected epidemiological infiltration of an atypical rotavirus (RV). PAGE analysis of 130 cases in 1985 and 1986 revealed that the RNA profiles were similar to that of group C RV in 12 cases. We performed IEM analysis on one of the strains and found it to be group C. The group C RV was detected for 2 months toward the end of the outbreak of group A RV infection. The ages of the group C RV infected patients were 4 years or older. We also studied the prevalence of antibody to group C in the stored sera that had been collected since 1971. Antibody was seldom found in the sera of patients under 3 years of age but it was found in 20-40% of those who were 4 years or older. The clinical manifestations of the group C RV infection were similar to those of group A, except that body temperature was slightly lower and other symptoms were generally milder.
我们最近发现了许多涉及大龄儿童以及有时涉及其家庭成员的肠胃炎病例。我们怀疑是非典型轮状病毒（RV）的流行病学感染。对1985年和1986年的130例病例进行的聚丙烯酰胺凝胶电泳（PAGE）分析显示，其中12例的RNA图谱与C组RV相似。我们对其中一株病毒进行了免疫电镜（IEM）分析，发现它属于C组。在A组RV感染爆发接近尾声时的两个月内检测到了C组RV。感染C组RV的患者年龄在4岁及以上。我们还研究了自1971年以来收集的储存血清中C组抗体的流行情况。在3岁以下患者的血清中很少发现抗体，但在4岁及以上患者中，20%-40%的人检测到了抗体。C组RV感染的临床表现与A组相似，只是体温略低，其他症状通常较轻。
