Laboratoire de Toxicologie Cellulaire, Faculté des Sciences, Université Badji-Mokhtar, 23000 Annaba, Algeria.
Environ Toxicol Pharmacol. 2007 Jan;23(1):132-4. doi: 10.1016/j.etap.2006.07.007. Epub 2006 Aug 4.
The purpose of this work was to investigate the interest of rabbits for studying pharmacology and toxicology of dietary nitrate. Twenty-one females were given 1, 300 and 600mg/l nitrate in drinking water for 11 weeks. Saliva and blood were analysed for nitrate/nitrite. There is a linear relationship between the amounts of nitrate ingested and amount of nitrate in saliva, contrary to what is observed in rats. However, salivary nitrite concentrations remain low, and nitrate reductase activity in the oral cavity of the rabbit seems very weak.
本研究旨在探讨兔子在膳食硝酸盐的药理学和毒理学研究中的应用价值。21 只雌性兔子被给予 1、300 和 600mg/L 的硝酸盐饮用水，为期 11 周。分析唾液和血液中的硝酸盐/亚硝酸盐。摄入的硝酸盐量与唾液中的硝酸盐量之间呈线性关系，这与在大鼠中观察到的情况相反。然而，唾液中亚硝酸盐浓度仍然较低，兔子口腔中的硝酸盐还原酶活性似乎非常弱。
