烟曲霉黏附宿主成分的分子机制。
Molecular mechanism of Aspergillus fumigatus adherence to host constituents.
机构信息
Departments of Medicine, and Microbiology and Immunology, McGill University, Duff Medical Building, 3775 University St, Rm D22, Montreal, Qc H3A 2B4, Canada.
出版信息
Curr Opin Microbiol. 2011 Aug;14(4):375-9. doi: 10.1016/j.mib.2011.07.006. Epub 2011 Jul 23.
Abstract
Inhaled conidia of Aspergillus fumigatus rapidly adhere to pulmonary epithelial cells and other host constituents. Identifying molecular mechanisms underlying A. fumigatus adherence has therefore been the focus of a number of studies aimed at identifying novel therapeutic targets. Early studies of A. fumigatus adherence to host constituents focused on fungal proteins, including RodA and AspF2. None of these proteins however has been found to play a role in virulence in experimental animal models. Recent advances have suggested an important role for fungal carbohydrate components of the cell wall and extracellular matrix in adherence, including sialic acid and mannose residues, and the newly described polysaccharide galactosaminogalactan. Despite these advances, the host cell receptors that are bound by these ligands remain unknown.
摘要
烟曲霉的吸入孢子迅速附着在肺上皮细胞和其他宿主成分上。因此，确定烟曲霉附着的分子机制一直是许多旨在确定新的治疗靶点的研究的重点。早期对烟曲霉与宿主成分附着的研究集中在真菌蛋白上，包括 RodA 和 AspF2。然而，这些蛋白质中没有一种被发现与实验动物模型中的毒力有关。最近的进展表明，细胞壁和细胞外基质中的真菌碳水化合物成分，包括唾液酸和甘露糖残基，以及新描述的多糖半乳糖氨基半乳糖，在附着中起着重要作用。尽管取得了这些进展，但这些配体结合的宿主细胞受体仍不清楚。
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