Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, Glostrup, Copenhagen, Denmark.
Cephalalgia. 2011 Sep;31(12):1274-81. doi: 10.1177/0333102411415878. Epub 2011 Jul 22.
The aim was to identify and describe migraine trigger factors in patients with familial hemiplegic migraine (FHM) from a population-based sample.
127 FHM patients were sent a questionnaire listing 16 trigger factors. Distinction was made between attacks of hemiplegic migraine (HM) and migraine with aura (MA) or without aura (MO) within each patient.
The response rate was 59% (75/127) of whom 57 (76%) had current HM attacks. Sixty-three per cent (47/75) reported at least one factor triggering HM, and 36% (27/75) reported at least one factor that often or always caused HM. Twenty per cent (15/75) reported only HM, whereas FHM in combinations with MA and MO were reported by 80% (60/75). Stress (with attacks either following or during the stress), bright light, intense emotional influences and sleeping too much or too little were the trigger factors mentioned by most.
Many FHM patients report trigger factors and one-third reported at least one trigger factor often or always triggering FHM. The typical triggers are the same as for MA. Patients should be educated to avoid these factors. The role of trigger factors in the onset of new or first attacks of FHM remains unknown.
本研究旨在从基于人群的样本中识别和描述家族性偏瘫性偏头痛（FHM）患者的偏头痛触发因素。
我们向 127 名 FHM 患者发送了一份问卷，列出了 16 种触发因素。在每位患者中，区分了偏瘫性偏头痛（HM）发作和有先兆偏头痛（MA）或无先兆偏头痛（MO）发作。
应答率为 59%（75/127），其中 57 名（76%）患者目前存在 HM 发作。63%（47/75）报告至少有一种触发 HM 的因素，36%（27/75）报告至少有一种经常或总是引发 HM 的因素。20%（15/75）仅报告 HM，而 FHM 与 MA 和 MO 组合的报告率为 80%（60/75）。压力（伴随或在压力下发作）、亮光、强烈的情绪影响以及睡眠过多或过少是大多数患者提到的触发因素。
许多 FHM 患者报告存在触发因素，三分之一的患者报告至少有一种触发因素经常或总是引发 FHM。典型的触发因素与 MA 相同。应教育患者避免这些因素。触发因素在 FHM 新发或首次发作中的作用尚不清楚。
