34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
Clin J Am Soc Nephrol. 2011 Aug;6(8):2047-53. doi: 10.2215/CJN.10751210. Epub 2011 Jul 22.
Over the last 5 years, the Chronic Kidney Disease in Children (CKiD) prospective cohort study has enrolled close to 600 children ages 1 to 16 years with mild to moderate chronic kidney disease (CKD). The main purpose of this interim report is to review the initial cross-sectional data and conclusions derived from the clinical studies conducted within CKiD in the context of findings from other pediatric CKD and end-stage renal disease (ESRD) registry and cohort studies. In particular, special emphasis was placed on studying four aspects of chronic kidney disease in children, including the identification of risk factors related to disease progression, the impact of CKD on neurocognition and quality of life (QoL), the cardiovascular morbidity associated with CKD, and identifying the causes and effects of growth failure in the context of mild to moderate kidney failure.
在过去的 5 年中，慢性肾脏病儿童（CKiD）前瞻性队列研究已经招募了近 600 名年龄在 1 至 16 岁之间的患有轻度至中度慢性肾脏病（CKD）的儿童。本中期报告的主要目的是审查 CKiD 内进行的临床研究的初始横断面数据和结论，并结合其他儿科 CKD 和终末期肾病（ESRD）登记和队列研究的结果进行分析。特别是，特别强调了研究儿童慢性肾脏病的四个方面，包括确定与疾病进展相关的危险因素、CKD 对神经认知和生活质量（QoL）的影响、与 CKD 相关的心血管发病率以及确定在轻度至中度肾功能衰竭的情况下生长障碍的原因和影响。
