Department of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Evid Based Complement Alternat Med. 2011;2011:812160. doi: 10.1093/ecam/neq063. Epub 2011 Mar 13.
This study was designed to investigate the effect of pulse width modulation electro-acupuncture (PWM-EA) on cardiovascular remodeling and nitric oxide (NO) in spontaneously hypertensive rats (SHR). Thirty-four male SHR were randomly divided into control, captopril, and two PWM-EA groups, which were treated with 350 Hz (SHR-350 Hz) and whole audio bandwith electro-acupuncture (SHR-WAB group) respectively, on the ST 36 point located on the outside of the hind leg. Systolic blood pressure (BP), plasma and myocardial NO were measured. Histological studies were also performed on the aortic wall and the left ventricle. The BP in the SHR-350 Hz, SHR-WAB and the captopril groups was lower than in the control group following the treatment (P < .05). The average aortic media wall thickness in the two electro-acupuncture groups was less than in the control group (P < .05). The left ventricle/heart weight ratio in the captopril and SHR-350 Hz groups was less than in the control group (P < .01), but was similar between the SHR-WAB and the control group (P > .05). The plasma and myocardium NO levels were elevated in the captopril and the SHR-350 Hz group (P < .05 and .01, resp.). The plasma level of NO in the SHR-WAB group was also higher than in the control group (P < .05). We concluded that pulse width modulation electro-acupuncture on the ST 36 point prevents the progression of hypertension and diminishes the cardiovascular remodeling in SHR. It also elevates plasma and cardiac NO in this animal model.
本研究旨在探讨脉冲宽度调制电针对自发性高血压大鼠（SHR）心血管重构和一氧化氮（NO）的影响。34 只雄性 SHR 随机分为对照组、卡托普利组和 2 个脉冲宽度调制电针组，分别在后腿外侧 ST 36 点给予 350Hz（SHR-350Hz 组）和全音频带宽电针（SHR-WAB 组）治疗。测量收缩压（BP）、血浆和心肌 NO。还对主动脉壁和左心室进行了组织学研究。与对照组相比，SHR-350Hz、SHR-WAB 和卡托普利组治疗后的 BP 降低（P<.05）。两组电针组的平均主动脉中层壁厚度均小于对照组（P<.05）。卡托普利组和 SHR-350Hz 组的左心室/心脏重量比均小于对照组（P<.01），但 SHR-WAB 组与对照组相似（P>.05）。卡托普利组和 SHR-350Hz 组的血浆和心肌 NO 水平升高（P<.05 和 P<.01）。SHR-WAB 组的血浆 NO 水平也高于对照组（P<.05）。我们得出结论，针刺 ST 36 点的脉冲宽度调制电针可预防高血压的进展并减轻 SHR 的心血管重构。它还可提高该动物模型中的血浆和心脏 NO 水平。
