简短通讯：吡喹酮、伊维菌素和奥芬达唑对猪带绦虫囊尾蚴的体外药效试验

Short Communication: In Vitro Efficacy Testing of Praziquantel, Ivermectin, and Oxfendazole against Taenia Solium Cysts.

作者信息

Cederberg S, Sikasunge C S, Andersson A, Johansen M V

机构信息

Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

出版信息

J Parasitol Res. 2012;2012:363276. doi: 10.1155/2012/363276. Epub 2011 Jun 8.

DOI:10.1155/2012/363276

PMID:21785697

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3135050/

Abstract

Oxfendazole is recommended as the drug of choice for treating porcine cysticercosis. The drug does not kill brain cysts and is not registered for use in pigs. Latest its safety in the recommended dose has been questioned. The aim of this study was to investigate two alternative anthelminthics. The efficacy of praziquantel and ivermectin was compared to oxfendazole In Vitro on Taenia solium. Cysts of T. solium were isolated from infected pork and incubated in culture media together with the drugs. The degree of evagination was used as effect measurement and determined after 6 hours. Praziquantel had a half maximal effective concentration (EC(50)) of value 0.006 ± 0.001 μg/mL. Ivermectin did not show any impact on the evagination in concentrations from 0.001 to 30 μg/mL and neither did oxfendazole in concentrations from 0.001 to 50 μg/mL.

摘要

奥芬达唑被推荐为治疗猪囊尾蚴病的首选药物。该药物不能杀死脑囊肿，且未注册用于猪。最近，其推荐剂量下的安全性受到质疑。本研究的目的是研究两种替代驱虫药。在体外将吡喹酮和伊维菌素与奥芬达唑对猪带绦虫的疗效进行了比较。从受感染的猪肉中分离出猪带绦虫囊肿，并与药物一起在培养基中培养。以外翻程度作为效果衡量指标，并在6小时后测定。吡喹酮的半数最大有效浓度（EC50）值为0.006±0.001μg/mL。伊维菌素在0.001至30μg/mL的浓度范围内对外翻没有任何影响，奥芬达唑在0.001至50μg/mL的浓度范围内也没有影响。