Department of Biophysics and Human Physiology, Medical University of Warsaw, Chalubinskiego 5, 02-004, Warsaw, Poland.
Cell Mol Biol Lett. 2011 Sep;16(3):493-514. doi: 10.2478/s11658-011-0019-7. Epub 2011 Jul 18.
Recently, stem cell biology has become an interesting topic, especially in the context of treating diseases and injuries using transplantation therapy. Several varieties of human stem cells have been isolated and identified in vivo and in vitro. Ideally, stem cells for regenerative medical application should be found in abundant quantities, harvestable in a minimally invasive procedure, then safely and effectively transplanted to either an autologous or allogenic host. The two main groups of stem cells, embryonic stem cells and adult stem cells, have been expanded to include perinatal stem cells. Mesenchymal stem cells from perinatal tissue may be particularly useful in the clinic for autologous transplantation for fetuses and newborns, and after banking in later stages of life, as well as for in utero transplantation in case of genetic disorders.This review highlights the characteristics and therapeutic potential of three human mesenchymal stem cell types obtained from perinatal sources: Wharton's jelly, the amnion, and the chorion.
最近，干细胞生物学已成为一个热门话题，尤其是在利用移植疗法治疗疾病和损伤方面。已经在体内和体外分离和鉴定了几种人类干细胞。理想情况下，用于再生医学应用的干细胞应该在大量存在，可通过微创程序收获，然后安全有效地移植到自体或同种异体宿主。胚胎干细胞和成人干细胞这两个主要的干细胞群已经扩展到包括围产期干细胞。来自围产期组织的间充质干细胞在临床上对于胎儿和新生儿的自体移植以及在生命后期储存后，以及在遗传疾病的宫内移植中可能特别有用。本综述强调了从围产期来源获得的三种人类间充质干细胞类型的特征和治疗潜力：Wharton 胶、羊膜和绒毛膜。
