钯催化乙烯基环丙烷（3+2）环加成方法合成 Melodinus 生物碱。
A palladium-catalyzed vinylcyclopropane (3+2) cycloaddition approach to the Melodinus alkaloids.
机构信息
The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 101-20, Pasadena, California 91125, USA.
出版信息
Org Lett. 2011 Aug 19;13(16):4474-6. doi: 10.1021/ol2017615. Epub 2011 Jul 25.
Abstract
A palladium-catalyzed (3+2) cycloaddition of a vinylcyclopropane and a β-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus alkaloids. The ABCD ring system of the natural product family is prepared in six steps from commercially available materials.
摘要
钯催化的乙烯基环丙烷和β-硝基苯乙烯的（3+2）环加成反应被用于快速构建美罗碱类生物碱的环戊烷核心。从商业可得的原料出发，通过六步反应即可制备天然产物家族的 ABCD 环系。
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