School of Medical Sciences, Institute of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
Biochem Soc Trans. 2011 Aug;39(4):874-80. doi: 10.1042/BST0390874.
The lack of reliable translational procedures applicable to both patients and experimental models are a major obstacle for the advancement of basic research as well as for the development of therapeutics. This is particularly relevant to neurodegenerative disorders such as AD (Alzheimer's disease), where the predictive validity of animal models and procedures applied preclinically have met with little success. Two approaches available for human diagnostics are currently experiencing major advancements in preclinical research: in vivo imaging using MRI (magnetic resonance imaging) or PET (positron-emission tomography) and recordings of brain electrical activity via surface EEG (electroencephalogram). The present paper reviews the results obtained so far in rodent AD models, and summarizes advantages and disadvantages of such procedures.
缺乏适用于患者和实验模型的可靠转化程序是推进基础研究和开发治疗方法的主要障碍。这对于神经退行性疾病（如 AD）尤其相关，动物模型和临床前应用的程序的预测有效性几乎没有成功。目前，有两种用于人类诊断的方法正在临床前研究中取得重大进展：使用 MRI（磁共振成像）或 PET（正电子发射断层扫描）进行体内成像，以及通过表面 EEG（脑电图）记录大脑电活动。本文综述了迄今为止在啮齿动物 AD 模型中获得的结果，并总结了这些程序的优缺点。
