Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, 7# Nanhai Road, Shandong 266071, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China.
Environ Toxicol Pharmacol. 2010 Jul;30(1):19-25. doi: 10.1016/j.etap.2010.03.008. Epub 2010 Mar 16.
Water samples collected from Bohai Bay were determined to describe the distributions of lead, mercury, and copper in this area, indicating that mean values of the three metals were 1.63μg/L, 4.85×10(-2)μg/L, and 2.68μg/L, respectively. Only lead exceeded the first class limit of seawater quality standard in China. Then, antioxidant enzymes, lipid peroxidation, and metabolic enzymes were investigated in bivalves (Chlamys farreri), exposed to three metals at the environmental concentration levels obtained from our investigation. Significantly reduced SOD, CAT and GPx activities, in lead-exposed group were observed and resulted in obvious lipid peroxidation. In contrast, mercury and copper did not show such clear oxidative stresses. In consistent with the oxidative stress variations, exposed only to lead caused a great inhibition on EROD activity. Multi-biomarker responses in bivalve when exposed to lead at the environmentally relevant concentration in Bohai Bay suggested that lead may possess a potential risk in this area.
从渤海湾采集的水样，用于描述该地区铅、汞和铜的分布情况，结果表明，这三种金属的平均值分别为 1.63μg/L、4.85×10(-2)μg/L 和 2.68μg/L。只有铅超过了中国海水水质标准的一级限值。然后，在从我们的调查中获得的环境浓度水平下，研究了三种金属对双壳类动物（海湾扇贝）抗氧化酶、脂质过氧化和代谢酶的影响。结果表明，在铅暴露组中，SOD、CAT 和 GPx 活性明显降低，并导致明显的脂质过氧化。相比之下，汞和铜并没有表现出如此明显的氧化应激。与氧化应激的变化一致，仅暴露于铅就会极大地抑制 EROD 活性。在渤海湾环境相关浓度下暴露于铅的双壳类动物的多生物标志物反应表明，铅在该地区可能存在潜在风险。
