Ito Masahiko, Kusunoki Hideki, Mochida Keiko, Yamaguchi Kazunari, Mizuochi Toshiaki
Department of Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, MusashiMurayama-shi, Tokyo 208-0011, Japan.
Adv Hematol. 2011;2011:835314. doi: 10.1155/2011/835314. Epub 2011 Jul 20.
Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases worldwide. It has been suggested that HCV infects not only hepatocytes but also mononuclear lymphocytes including B cells that express the CD81 molecule, a putative HCV receptor. HCV infection of B cells is the likely cause of B-cell dysregulation disorders such as mixed cryoglobulinemia, rheumatoid factor production, and B-cell lymphoproliferative disorders that may evolve into non-Hodgkin's lymphoma (NHL). Epidemiological data indicate an association between HCV chronic infection and the occurrence of B-cell NHL, suggesting that chronic HCV infection is associated at least in part with B-cell lymphomagenesis. In this paper, we aim to provide an overview of recent literature, including our own, to elucidate a possible role of HCV chronic infection in B-cell lymphomagenesis.
丙型肝炎病毒（HCV）已被公认为全球慢性肝病的主要病因。有研究表明，HCV不仅感染肝细胞，还感染包括表达CD81分子（一种假定的HCV受体）的B细胞在内的单核淋巴细胞。B细胞感染HCV可能是导致B细胞失调性疾病的原因，如混合性冷球蛋白血症、类风湿因子产生以及可能发展为非霍奇金淋巴瘤（NHL）的B细胞淋巴增殖性疾病。流行病学数据表明，HCV慢性感染与B细胞NHL的发生之间存在关联，这表明慢性HCV感染至少部分与B细胞淋巴瘤的发生有关。在本文中，我们旨在综述包括我们自己的研究在内的近期文献，以阐明HCV慢性感染在B细胞淋巴瘤发生中的可能作用。
