Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar 125001, India.
Evid Based Complement Alternat Med. 2011;2011:898593. doi: 10.1093/ecam/neq021. Epub 2011 Jun 5.
Chyawanprash (Chy) is an ayurvedic formulation commonly consumed in Indian households. Chy is a comprehensive herbal tonic, prepared from around 50 herbs employing anwala (Emblica officinalis) as the basic ingredient. The present study was undertaken to explore the beneficial effects of Chy (at the dose of 1 and 2% w/w of diet) administered daily for 15 successive days in mice with memory deficits. A total of 228 mice divided in 38 groups were employed in this study. Morris water maze, Hebb-Williams maze and elevated plus maze served as exteroceptive memory models, whereas scopolamine (Sco)-induced amnesia and alprazolam (Alp)-induced amnesia served as interoceptive memory models. The brain acetylcholinesterase activity, brain thiobarbituric acid reactive substances (TBARS) and reduced glutathione levels (GSH) were also estimated. The administration of Chy for 15 consecutive days significantly protected the animals from developing memory impairment. Furthermore, there was a significant decrease in brain TBARS and increase in GSH levels after administration of Chy (2% w/w), thereby indicating decreased free radical generation and increased scavenging of free radical, respectively. Thus, Chy may prove to be a useful remedy for the management of Alzheimer's disease owing to its antioxidant effect, pro-cholinergic action and/or antiamnesic potential.
恰瓦普拉萨（Chy）是一种印度家庭常用的阿育吠陀配方。Chy 是一种综合草药滋补品，由大约 50 种草药制成，采用安瓦拉（Emblica officinalis）作为基本成分。本研究旨在探索恰瓦普拉萨（Chy）（剂量为饮食的 1%和 2%w/w）连续 15 天给药对记忆障碍小鼠的有益作用。这项研究共使用了 228 只小鼠，分为 38 组。Morris 水迷宫、Hebb-Williams 迷宫和高架十字迷宫用作外感受性记忆模型，而东莨菪碱（Sco）诱导的遗忘和阿普唑仑（Alp）诱导的遗忘用作内感受性记忆模型。还估计了大脑乙酰胆碱酯酶活性、大脑硫代巴比妥酸反应物质（TBARS）和还原型谷胱甘肽水平（GSH）。连续 15 天给予恰瓦普拉萨（Chy）可显著保护动物免受记忆障碍的发生。此外，恰瓦普拉萨（Chy）（2%w/w）给药后大脑 TBARS 显著降低，GSH 水平显著升高，分别表明自由基生成减少和自由基清除增加。因此，恰瓦普拉萨（Chy）可能因其抗氧化作用、拟胆硷能作用和/或抗遗忘潜力而被证明是治疗阿尔茨海默病的有效药物。
