Cabrera Marcela P, Chihuailaf Ricardo H
Escuela de Graduados, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, P.O. Box 567, 5110566 Valdivia, Chile.
Vet Med Int. 2011;2011:905153. doi: 10.4061/2011/905153. Epub 2011 Jul 12.
Oxygen-derived free radicals are normally generated in many pathways. These radicals can interact with various cellular components and induce cell injury. When free radicals exceed the antioxidant capacity, cell injury causes diverse pathologic changes in the organs. The imbalance between the generation of free radicals and antioxidant defence is known as oxidative stress. The eye can suffer the effect of oxidative damage due to the etiopathogenesis of some pathological changes related to oxidative stress. This paper reviews the role of oxidative stress in the onset and progression of damage in different eye structures, the involvement of the antioxidant network in protecting and maintaining the homeostasis of this organ, and the potential assessment methodologies used in research and in some cases in clinical practice.
氧衍生的自由基通常通过多种途径产生。这些自由基可与各种细胞成分相互作用并导致细胞损伤。当自由基超过抗氧化能力时，细胞损伤会在器官中引起各种病理变化。自由基生成与抗氧化防御之间的失衡被称为氧化应激。由于某些与氧化应激相关的病理变化的发病机制，眼睛会受到氧化损伤的影响。本文综述了氧化应激在不同眼部结构损伤的发生和发展中的作用、抗氧化网络在保护和维持该器官内环境稳定中的作用，以及在研究和某些临床实践中使用的潜在评估方法。
