Zgavc Tine, Ceulemans An-Gaëlle, Sarre Sophie, Michotte Yvette, Hachimi-Idrissi Said
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Stroke Res Treat. 2011;2011:689290. doi: 10.4061/2011/689290. Epub 2011 Jul 12.
Stroke remains a disease with a serious impact on quality of life but few effective treatments exist. There is an urgent need to develop and/or improve neuroprotective strategies to combat this. Many drugs proven to be neuroprotective in experimental models fail to improve patient outcome in a clinical setting. An emerging treatment, therapeutic hypothermia (TH), is a promising neuroprotective therapy in stroke management. Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. This paper discusses the possible opportunities and limitations of the use of TH in animal models and the translation into the clinic.
中风仍然是一种严重影响生活质量的疾病，但有效的治疗方法却很少。迫切需要开发和/或改进神经保护策略来应对这一问题。许多在实验模型中被证明具有神经保护作用的药物在临床环境中并不能改善患者的预后。一种新兴的治疗方法——治疗性低温（TH），在中风管理中是一种很有前景的神经保护疗法。在实验模型和小型临床试验中对TH进行的多项研究已显示出有益效果。尽管如此，由于方法学方面的考虑以及与低温相关的并发症，TH在临床环境中的应用仍然不足。本文讨论了在动物模型中使用TH以及将其转化应用于临床的可能机会和局限性。
