PUCRS, Porto Alegre, RS, Brazil.
Naunyn Schmiedebergs Arch Pharmacol. 2011 Sep;384(3):265-75. doi: 10.1007/s00210-011-0668-0. Epub 2011 Jul 23.
The effects of Phyllanthus niruri hydroalcoholic extract and the isolated compounds quercetin, rutin, and gallic acid were examined in the mouse model of cyclophosphamide (CYP)-induced hemorrhagic cystitis (HC). HC was induced by a single CYP injection (300 mg/kg, IP), and the animals were evaluated 4 and 6 h after. Some animals were orally treated with the reference compound 2-mercaptoethane sodium sulfonate (Mesna) 80 mg/kg (30 min before CYP) and 160 mg/kg (2 h after CYP). Other groups were treated with P. niruri extract (30 and 50 mg/kg), or quercetin, rutin, and gallic acid (10 and 20 mg/kg), given orally, at the same intervals described for Mesna. P. niruri extract and its active components produced a significant attenuation of the nociception, edema, and hemorrhage evoked by CYP, which was similar to that seen for Mesna. Gallic acid and rutin displayed greater anti-inflammatory effects, whereas quercetin presented superior antinociceptive activities. Noteworthy is that P. niruri extract and compounds significantly reduced CYP-induced liver lipid peroxidation. Our results shed new light on the beneficial effects of P. niruri extract and its active compounds in attenuating the collateral effects elicited by the chemotherapeutic agent CYP.
水飞蓟宾醇提物及其分离化合物槲皮素、芦丁和没食子酸对环磷酰胺（CYP）诱导的出血性膀胱炎（HC）小鼠模型的影响进行了研究。HC 通过单次 CYP 注射（300mg/kg，IP）诱导，在 4 和 6 小时后对动物进行评估。一些动物用参考化合物 2-巯基乙磺酸单钠盐（Mesna）30min 前（CYP 前）和 2 小时后（CYP 后）进行了 80mg/kg（CYP 前）和 160mg/kg（CYP 后）的口服治疗。其他组以相同的时间间隔接受水飞蓟宾提取物（30 和 50mg/kg）或槲皮素、芦丁和没食子酸（10 和 20mg/kg）治疗。水飞蓟宾提取物及其活性成分对 CYP 引起的疼痛、水肿和出血有显著的抑制作用，与 Mesna 相似。没食子酸和芦丁表现出更强的抗炎作用，而槲皮素则具有更强的镇痛作用。值得注意的是，水飞蓟宾提取物和化合物显著降低了 CYP 诱导的肝脂质过氧化。我们的结果为水飞蓟宾提取物及其活性化合物减轻化疗药物 CYP 引起的副作用提供了新的证据。
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