Department of Neurosurgery and Shenzhen Key Laboratory of Neurosurgery, Shenzhen University 1st Affiliated Hospital, Shenzhen Second People's Hospital, Shenzhen, China.
Department of Clinical Medicine College, Anhui Medical University, Hefei, China.
Cancer Sci. 2018 Sep;109(9):2651-2659. doi: 10.1111/cas.13714. Epub 2018 Aug 3.
Glioma is the most common central nervous system tumor and associated with poor prognosis. Identifying effective diagnostic biomarkers for glioma is particularly important in order to guide optimizing treatment. MicroRNAs (miRNAs) have drawn much attention because of their diagnostic value in diverse cancers, including glioma. We summarized studies to identify the potential diagnostic values of miRNAs in glioma patients. We included articles reporting miRNAs for differentiation of glioma patients from controls. We calculated sensitivities, specificities, and area under the curves (AUC) of individual miRNA and miRNA panels. We found that overall sensitivity, specificity, and AUC of miRNAs in diagnosis of glioma were 85% (95% confidence interval [CI]: 0.81-0.89), 90% (95% CI 0.85-0.93), and 93% (95% CI 0.91-0.95), respectively. Meta-regression analysis showed that the detection of miRNAs expression in cerebrospinal fluid (CSF) and brain tissue largely improved the diagnostic accuracy. Likewise, panels of multiple miRNAs could enhance the pooled sensitivity. Moreover, AUC of miR-21 was 0.88, with 86% sensitivity and 94% specificity. This study demonstrated that miRNAs could function as potential diagnosis markers in glioma. Detection of miRNAs in CSF and brain tissue displays high accuracy in the diagnosis of glioma.
脑胶质瘤是最常见的中枢神经系统肿瘤，预后不良。因此，寻找有效的脑胶质瘤诊断生物标志物对于指导优化治疗尤为重要。微小 RNA（miRNA）因其在多种癌症（包括脑胶质瘤）中的诊断价值而备受关注。我们总结了旨在确定 miRNA 对脑胶质瘤患者诊断价值的研究。我们纳入了报道 miRNA 可区分脑胶质瘤患者和对照的文章。我们计算了单个 miRNA 和 miRNA 组合的灵敏度、特异度和曲线下面积（AUC）。结果发现，miRNA 对脑胶质瘤的总体诊断灵敏度、特异度和 AUC 分别为 85%（95%CI：0.81-0.89）、90%（95%CI：0.85-0.93）和 93%（95%CI：0.91-0.95）。Meta 回归分析表明，脑脊液（CSF）和脑组织中 miRNA 表达的检测极大地提高了诊断准确性。同样，多个 miRNA 的组合也可以提高合并灵敏度。此外，miR-21 的 AUC 为 0.88，灵敏度为 86%，特异度为 94%。本研究表明，miRNA 可以作为脑胶质瘤潜在的诊断标志物。CSF 和脑组织中 miRNA 的检测在脑胶质瘤的诊断中具有较高的准确性。
