Pirzadeh Akbar, Doustmohammadian Najmeh, Khoshbaten Manochehr, Doustmohammadion Sorayya
Otorhinolaryngology Dept, Ardebil University of Medical Sciences, Ardebil, Iran.
Asian Pac J Cancer Prev. 2011;12(4):897-900.
To investigate the possible role of Helicobacter pylori as a cause of squamous cell carcinoma of larynx in a case-control study in an otolaryngology ward at an academic university.
A total of 65 patients with laryngeal cancer and 65 matched cancer-free controls underwent esophagogastroduodenoscopy and biopsy of antral and body regions of the stomach for evaluation of Helicobacter pylori infection.
The proportion of subjects with a positive rapid urease test for gastric infection was similar between the two groups (49.2 % in cases vs. 40% in controls). However, a positive rapid urease test for body was less frequently seen in patients with laryngeal cancer whereas a positive rapid urease test for antrum was significantly higher (P=0.04).
Our study failed to show Helicobacter pylori as one of the etiologies of laryngeal cancer. However, it supported the hypothesis that colonization of Helicobacter pylori only in the gastric body might have a protective effect against laryngeal cancer with decreasing gastric acid while antral Helicobacter pylori, increasing gastric acid due to G cell hyperplasia, may be a predisposing factor for laryngeal cancer, with acid reflux as a possible underlying etiology.
在一所学术性大学的耳鼻喉科病房进行一项病例对照研究，以调查幽门螺杆菌作为喉鳞状细胞癌病因的可能作用。
总共65例喉癌患者和65例匹配的无癌对照者接受了食管胃十二指肠镜检查，并对胃窦和胃体区域进行活检，以评估幽门螺杆菌感染情况。
两组中胃感染快速尿素酶试验阳性的受试者比例相似（病例组为49.2%，对照组为40%）。然而，喉癌患者中胃体快速尿素酶试验阳性较少见，而胃窦快速尿素酶试验阳性则显著更高（P=0.04）。
我们的研究未能表明幽门螺杆菌是喉癌的病因之一。然而，它支持了这样一种假说，即仅胃体部幽门螺杆菌定植可能通过降低胃酸对喉癌具有保护作用，而胃窦幽门螺杆菌由于G细胞增生导致胃酸增加，可能是喉癌的一个易感因素，胃酸反流可能是潜在病因。
