Guilemany Josep Maria, Langdon Cristobal, Ballesteros Ferran, Blanch Jose Luis
Department of Otorhinolaryngology Head and Neck Surgery, Hospital Clínic I Universitari de Barcelona, University of Barcelona, c/Villarroel, 170, 08036, Barcelona, Spain.
Eur Arch Otorhinolaryngol. 2014 Sep;271(9):2539-43. doi: 10.1007/s00405-013-2794-4. Epub 2013 Nov 6.
The aim of this study is to assess the correlation between the Helicobacter pylori (H. pylori) serologic status of patients who underwent for curative resection for squamous cell carcinoma of the larynx and hypopharynx and their prognosis. From April 2004 to March 2005, we included eighty patients with laryngeal and hypopharyngeal cancer. Control group consisted of 20 healthy patients and 10 patients with Reinke's edema. Serologic status was assessed using an enzyme-linked immunosorbent assay kit for immunoglobulin G. Patients were followed for 5 years. H. pylori-positive serologic status was statistically significant for the case subjects (70.6 v/s 29.4 %; p < 0.001). Mean overall and disease-free survival were 50.7 months (range 46.9-54.5) and 52.1 months (range 48.3-55.7), respectively. H. pylori-positive serologic status was not associated with a poor prognosis in the Cox regression model (p = 0.77). We observed a positive association between H. pylori infection and laryngeal and hypopharyngeal cancer. But we fail to confirm that the presence of H. pylori infection is associated with poor outcome or a higher recurrence rate.
本研究旨在评估接受喉和下咽鳞状细胞癌根治性切除术患者的幽门螺杆菌（H. pylori）血清学状态与其预后之间的相关性。2004年4月至2005年3月，我们纳入了80例喉癌和下咽癌患者。对照组由20名健康患者和10例任克氏水肿患者组成。使用免疫球蛋白G酶联免疫吸附测定试剂盒评估血清学状态。对患者进行了5年的随访。病例组中幽门螺杆菌血清学阳性状态具有统计学意义（70.6%对29.4%；p<0.001）。总体平均生存期和无病生存期分别为50.7个月（范围46.9 - 54.5个月）和52.1个月（范围48.3 - 55.7个月）。在Cox回归模型中，幽门螺杆菌血清学阳性状态与预后不良无关（p = 0.77）。我们观察到幽门螺杆菌感染与喉癌和下咽癌之间存在正相关。但我们未能证实幽门螺杆菌感染的存在与不良预后或更高的复发率相关。
