Department of Surgery, UCSD, School of Medicine, La Jolla, California, USA.
Breast J. 2011 Sep-Oct;17(5):485-9. doi: 10.1111/j.1524-4741.2011.01117.x. Epub 2011 Jul 25.
Adenoid cystic carcinoma (ACC) is an uncommon type of breast cancer. There are limited data about its epidemiology, tumor characteristics, and outcomes. Using a large, population-based data base, this study aimed to identify specific characteristics of patients with adenoid cystic breast cancer, investigate its natural history, and determine its long-term prognosis. The California Cancer Registry, a population-based registry, was reviewed from the years 1988 to 2006. The data were analyzed with relation to patient age, tumor size and stage, and overall survival. Relative cumulative actuarial survival was determined using the Berkson-Gage life table method. A total of 244 cases of invasive adenoid cystic cancer were identified in women during this time period. The patients' median age was 61.9 years. Most cases were diagnosed in non-Hispanic White women (82%, n = 200), followed by African American (6%, n = 15), Asian/Pacific-Islander (5.7%, n = 14) and Hispanic women (4.4%, n = 12). The remainder of the patients was of unknown or other ethnicity. Tumors were between 1 and 140 mm in size. At the time of diagnosis, 92% (n = 225) of patients had localized disease, 5% (n = 12) of patients had regional disease, and even fewer (n = 7) had either distant or unknown staged disease. Lymph node involvement was not present in any tumors smaller than 1.4 cm. The relative cumulative survival of patients with adenoid cystic breast carcinoma was 95.6% at 5 years and 94.9% at 10 years. ACC of the breast is a rare disease with an overall good prognosis. Knowing that this cancer usually presents as localized disease, with lymph node involvement seen only with larger tumors, can help clinicians plan the operative management of these tumors.
腺样囊性癌（ACC）是一种罕见的乳腺癌类型。关于其流行病学、肿瘤特征和结局的数据有限。本研究利用一个大型的基于人群的数据库，旨在确定乳腺腺样囊性癌患者的特定特征，研究其自然病史，并确定其长期预后。从 1988 年到 2006 年，对加利福尼亚癌症登记处（一个基于人群的登记处）进行了回顾。根据患者年龄、肿瘤大小和分期以及总体生存率对数据进行了分析。使用 Berkson-Gage 寿命表法确定相对累积实际生存率。在此期间，共发现 244 例浸润性腺样囊性癌女性患者。患者的中位年龄为 61.9 岁。大多数病例发生在非西班牙裔白人女性（82%，n=200），其次是非洲裔美国人（6%，n=15）、亚裔/太平洋岛民（5.7%，n=14）和西班牙裔女性（4.4%，n=12）。其余患者的种族未知或属于其他种族。肿瘤大小为 1 至 140mm。在诊断时，92%（n=225）的患者为局限性疾病，5%（n=12）的患者为区域性疾病，仅有少数（n=7）患者为远处或未知分期疾病。淋巴结受累在任何小于 1.4cm 的肿瘤中均不存在。乳腺腺样囊性癌患者的相对累积生存率为 5 年时 95.6%，10 年时 94.9%。乳腺腺样囊性癌是一种罕见疾病，总体预后良好。了解这种癌症通常表现为局限性疾病，只有较大的肿瘤才会出现淋巴结受累，有助于临床医生为这些肿瘤制定手术管理计划。
