Department of Gastroenterology/Hepatology, Digestive Disease Institute, the Cleveland Clinic Foundation, Cleveland, Ohio, USA.
J Dig Dis. 2011 Aug;12(4):245-56. doi: 10.1111/j.1751-2980.2011.00511.x.
One of typical examples of liver-gut cross talk is the interaction and impact of inflammatory bowel disease (IBD) and hepatobiliary (HB) abnormalities on each other's disease course. There are several layers of association between IBD and HB diseases: (i) HB diseases and IBD share pathogenetic mechanisms; (ii) HB diseases parallel structural and pathophysiological changes seen with IBD; and (iii) hepatic toxicity is associated with medical therapy for IBD. Interdisciplinary approach, involving gastroenterologists, hepatologists and, in advanced cases, general, colorectal, and liver transplant surgeons, is advocated.
肝肠对话的典型范例之一是炎症性肠病（IBD）和肝胆（HB）异常相互作用和影响彼此的病程。IBD 和 HB 疾病之间存在几个关联层面：（i）HB 疾病和 IBD 具有共同的发病机制；（ii）HB 疾病与 IBD 中所见的结构和病理生理学变化平行；（iii）肝毒性与 IBD 的医学治疗有关。提倡采用涉及胃肠病学家、肝病学家的跨学科方法，在复杂病例中还需要普外科、结直肠科和肝移植外科医生的参与。
