MRS 和 MRSI 在分子医学中的指导作用：癌症中胆碱和葡萄糖代谢的靶向和监测。
MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer.
机构信息
Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
NMR Biomed. 2011 Jul;24(6):673-90. doi: 10.1002/nbm.1751.
Abstract
MRS and MRSI are valuable tools for the detection of metabolic changes in tumors. The currently emerging era of molecular medicine, which is shaped by molecularly targeted anticancer therapies combined with molecular imaging of the effects of such therapies, requires powerful imaging technologies that are able to detect molecular information. MRS and MRSI are such technologies that are able to detect metabolites arising from glucose and choline metabolism in noninvasive in vivo settings and at higher resolution in tissue samples. The roles played by MRS and MRSI in the diagnosis of different types of cancer, as well as in the early monitoring of the tumor response to traditional chemotherapies, are reviewed. The emerging roles of MRS and MRSI in the development and detection of novel targeted anticancer therapies that target oncogenic signaling pathways or markers in choline or glucose metabolism are discussed.
摘要
MRS 和 MRSI 是检测肿瘤代谢变化的有价值的工具。目前，分子靶向抗癌治疗与这些治疗效果的分子成像相结合所形成的分子医学新时代，需要能够检测分子信息的强大成像技术。MRS 和 MRSI 就是能够在非侵入性的体内环境中检测葡萄糖和胆碱代谢产生的代谢物，并在组织样本中以更高的分辨率进行检测的技术。本文综述了 MRS 和 MRSI 在不同类型癌症的诊断以及早期监测肿瘤对传统化疗的反应中的作用。还讨论了 MRS 和 MRSI 在开发和检测针对胆碱或葡萄糖代谢中的致癌信号通路或标志物的新型靶向抗癌治疗中的新作用。
相似文献
1
MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer.MRS 和 MRSI 在分子医学中的指导作用：癌症中胆碱和葡萄糖代谢的靶向和监测。
NMR Biomed. 2011 Jul;24(6):673-90. doi: 10.1002/nbm.1751.
2
Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents.利用肿瘤代谢进行分子靶向抗癌药物治疗活性的无创成像。
Cell Cycle. 2011 Sep 1;10(17):2883-93. doi: 10.4161/cc.10.17.17192.
3
MR evaluation of response to targeted treatment in cancer cells.磁共振评价肿瘤细胞靶向治疗的反应。
NMR Biomed. 2011 Jul;24(6):648-72. doi: 10.1002/nbm.1658. Epub 2011 Mar 8.
4
17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2.17-烯丙氨基-17-去甲氧基格尔德霉素治疗导致磁共振波谱检测到胆碱代谢物升高，与胆碱转运蛋白 SLC44A1 和磷脂酶 A2 的表达增加有关。
Breast Cancer Res. 2010;12(5):R84. doi: 10.1186/bcr2729. Epub 2010 Oct 14.
5
Metabolic tumor imaging using magnetic resonance spectroscopy.磁共振波谱代谢肿瘤成像。
Semin Oncol. 2011 Feb;38(1):26-41. doi: 10.1053/j.seminoncol.2010.11.001.
6
Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.关注癌症胆碱磷脂代谢中的甘油磷酸胆碱途径。
NMR Biomed. 2019 Oct;32(10):e4112. doi: 10.1002/nbm.4112. Epub 2019 Jun 11.
7
Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma.儿童弥漫性内生性脑桥胶质瘤的单体素和多体素质子波谱分析。
Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):774-9. doi: 10.1016/j.ijrobp.2012.01.032. Epub 2012 Mar 23.
8
[1H magnetic resonance spectroscopy of the prostate].[前列腺的1H磁共振波谱分析]
Radiologe. 2003 Jun;43(6):481-8. doi: 10.1007/s00117-003-0902-y.
9
Cancer metabolism in a snapshot: MRS(I).快照式癌症代谢研究：MRS（I）。
NMR Biomed. 2019 Oct;32(10):e4054. doi: 10.1002/nbm.4054. Epub 2019 Jan 11.
10
Proton MR spectroscopy of the prostate.前列腺的质子磁共振波谱分析。
Eur J Radiol. 2007 Sep;63(3):351-60. doi: 10.1016/j.ejrad.2007.06.024. Epub 2007 Aug 20.
引用本文的文献
1
Choline in immunity: a key regulator of immune cell activation and function.胆碱在免疫中的作用：免疫细胞激活与功能的关键调节因子
Front Immunol. 2025 Aug 1;16:1617077. doi: 10.3389/fimmu.2025.1617077. eCollection 2025.
2
Use of Radiomics in Characterizing Tumor Hypoxia.放射组学在肿瘤缺氧特征描述中的应用。
Int J Mol Sci. 2025 Jul 11;26(14):6679. doi: 10.3390/ijms26146679.
3
Utility of Magnetic Resonance Spectroscopy and Perfusion Imaging in Differentiating Brain Tumors From Mimics in a Tertiary Hospital in the Philippines.磁共振波谱和灌注成像在菲律宾一家三级医院鉴别脑肿瘤与类似病症中的应用
Cureus. 2025 Mar 26;17(3):e81258. doi: 10.7759/cureus.81258. eCollection 2025 Mar.
4
Portable multi-parametric microscopy for noninvasive metabolic and vascular imaging of orthotopic tongue cancer models .用于原位舌癌模型无创代谢和血管成像的便携式多参数显微镜
J Biomed Opt. 2025 Feb;30(Suppl 2):S23905. doi: 10.1117/1.JBO.30.S2.S23905. Epub 2025 Apr 23.
5
Tumor hypoxia unveiled: insights into microenvironment, detection tools and emerging therapies.肿瘤缺氧揭秘：对微环境、检测工具和新兴疗法的深入了解。
Clin Exp Med. 2024 Oct 3;24(1):235. doi: 10.1007/s10238-024-01501-1.
6
Role of Magnetic Resonance Spectroscopy in Evaluating Choline Levels in Gallbladder Carcinoma: A Comprehensive Review.磁共振波谱在评估胆囊癌中胆碱水平的作用：一项综述
Cureus. 2024 Aug 5;16(8):e66205. doi: 10.7759/cureus.66205. eCollection 2024 Aug.
7
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation.烯醇化酶-1 的糖酵解酶的兼职功能促进胆堿磷脂代谢和肿瘤细胞增殖。
Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2209435120. doi: 10.1073/pnas.2209435120. Epub 2023 Apr 3.
8
Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study.阿磷酸胆碱对胶质母细胞瘤患者生存的影响：一项回顾性单中心研究
J Clin Med. 2022 Oct 13;11(20):6052. doi: 10.3390/jcm11206052.
9
MRI techniques for immunotherapy monitoring.磁共振成像技术在免疫疗法监测中的应用。
J Immunother Cancer. 2022 Sep;10(9). doi: 10.1136/jitc-2022-004708.
10
Emerging Role for 7T MRI and Metabolic Imaging for Pancreatic and Liver Cancer.7T磁共振成像和代谢成像在胰腺癌和肝癌中的新兴作用。
Metabolites. 2022 Apr 30;12(5):409. doi: 10.3390/metabo12050409.
本文引用的文献
1
Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose.瑞典 AMORIS 研究中的前列腺癌风险：甘油三酯、总胆固醇和葡萄糖之间的相互作用。
Cancer. 2011 May 15;117(10):2086-95. doi: 10.1002/cncr.25758. Epub 2010 Nov 29.
2
13C high-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns.13C 高分辨率-魔角旋转磁共振波谱分析揭示了两种基因表达模式不同的乳腺癌异种移植模型之间葡萄糖代谢的差异。
NMR Biomed. 2011 Dec;24(10):1243-52. doi: 10.1002/nbm.1683. Epub 2011 Apr 4.
3
Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer.葡萄糖代谢基因多态性与胰腺癌的临床结局。
Cancer. 2011 Feb 1;117(3):480-91. doi: 10.1002/cncr.25612. Epub 2010 Sep 15.
4
31P magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences.3T 下人体大脑中磷单酯和双酯的极化转移 31P 磁共振波谱成像：与年龄和空间差异的关系。
NMR Biomed. 2010 Oct;23(8):968-76. doi: 10.1002/nbm.1523.
5
The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.磷酸肌醇 3-激酶抑制剂 PI-103 下调胆碱激酶α，导致磁共振波谱检测到的磷酸胆碱和总胆碱减少。
Cancer Res. 2010 Jul 1;70(13):5507-17. doi: 10.1158/0008-5472.CAN-09-4476. Epub 2010 Jun 15.
6
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo.DNP 多化合物极化允许在体内同时评估多种酶活性。
J Magn Reson. 2010 Jul;205(1):141-7. doi: 10.1016/j.jmr.2010.04.012. Epub 2010 Apr 27.
7
Inhibition of phosphatidylcholine-specific phospholipase C downregulates HER2 overexpression on plasma membrane of breast cancer cells.抑制磷酯酰胆碱特异性磷酯酶 C 下调乳腺癌细胞膜上 HER2 的过度表达。
Breast Cancer Res. 2010;12(3):R27. doi: 10.1186/bcr2575. Epub 2010 May 12.
8
3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy.3-溴丙酮酸：一种新型靶向糖酵解药物，有望成为癌症治疗的新方法。
Curr Pharm Biotechnol. 2010 Aug;11(5):510-7. doi: 10.2174/138920110791591427.
9
In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose.应用 13C-1 标记的葡萄糖后人体脑部肿瘤的活体 13C 磁共振波谱分析
Magn Reson Imaging. 2010 Jun;28(5):690-7. doi: 10.1016/j.mri.2010.03.006.
10
Targeting metabolic transformation for cancer therapy.针对癌症治疗的代谢重编程。
Nat Rev Cancer. 2010 Apr;10(4):267-77. doi: 10.1038/nrc2817. Epub 2010 Mar 19.
Zotero 插件