Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
NMR Biomed. 2011 Jul;24(6):673-90. doi: 10.1002/nbm.1751.
MRS and MRSI are valuable tools for the detection of metabolic changes in tumors. The currently emerging era of molecular medicine, which is shaped by molecularly targeted anticancer therapies combined with molecular imaging of the effects of such therapies, requires powerful imaging technologies that are able to detect molecular information. MRS and MRSI are such technologies that are able to detect metabolites arising from glucose and choline metabolism in noninvasive in vivo settings and at higher resolution in tissue samples. The roles played by MRS and MRSI in the diagnosis of different types of cancer, as well as in the early monitoring of the tumor response to traditional chemotherapies, are reviewed. The emerging roles of MRS and MRSI in the development and detection of novel targeted anticancer therapies that target oncogenic signaling pathways or markers in choline or glucose metabolism are discussed.
MRS 和 MRSI 是检测肿瘤代谢变化的有价值的工具。目前，分子靶向抗癌治疗与这些治疗效果的分子成像相结合所形成的分子医学新时代，需要能够检测分子信息的强大成像技术。MRS 和 MRSI 就是能够在非侵入性的体内环境中检测葡萄糖和胆碱代谢产生的代谢物，并在组织样本中以更高的分辨率进行检测的技术。本文综述了 MRS 和 MRSI 在不同类型癌症的诊断以及早期监测肿瘤对传统化疗的反应中的作用。还讨论了 MRS 和 MRSI 在开发和检测针对胆碱或葡萄糖代谢中的致癌信号通路或标志物的新型靶向抗癌治疗中的新作用。
