Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
NMR Biomed. 2011 Jul;24(6):750-63. doi: 10.1002/nbm.1731.
This article provides a literature review of the use of MRI in monitoring the treatment response of soft tissue sarcomas. The basic classification and physiology of soft tissue tumors are introduced. Then, the major treatment options for soft tissue sarcomas are summarized with brief coverage of possible responses and grading systems. Four major branches of MRI techniques are covered, including conventional T(1) - and T(2) -weighted imaging, contrast-enhanced MRI, MR diffusion and perfusion imaging, and MRS, with a focus on the tumor microenvironment. Although this literature survey focuses on recent clinical developments using these MRI techniques, research venues in preclinical studies, as well as in potential applications other than soft tissue sarcomas, are also included when comparable and/or mutually supporting. Examples from other less-discussed MRI modalities are also briefly covered, not only to complement, but also to expand, the scope and depth of information for various kinds of lesions.
本文对 MRI 在软组织肉瘤治疗反应监测中的应用进行了文献回顾。介绍了软组织肿瘤的基本分类和生理学。然后，总结了软组织肉瘤的主要治疗选择，并简要介绍了可能的反应和分级系统。涵盖了 MRI 技术的四个主要分支，包括常规 T1 和 T2 加权成像、对比增强 MRI、MR 扩散和灌注成像以及 MRS，重点关注肿瘤微环境。尽管本文献综述侧重于使用这些 MRI 技术的最新临床进展，但在临床前研究以及软组织肉瘤以外的潜在应用领域的研究场所也包括在内，只要具有可比性和/或相互支持。还简要介绍了其他讨论较少的 MRI 模式的例子，不仅是为了补充，也是为了扩展各种病变的信息范围和深度。
