Vayssairat M, Baudot N, Blaison N, Evenou P, Gilard M, Mathieu J F
Service de Médecine vasculaire, Hôpital Broussais, Paris.
J Mal Vasc. 1990;15(1):82-5.
Vascular reactivity is an hemodynamic parameter, hard to quantify because its reproducibility is usually unpredictable. Cold is the most common stress used to trigger vasoconstriction in human clinical practice. Cold tests are urgently needed to fulfill the following purposes: A physiological tool to investigate cold reactivity in vascular diseases and secondly an objective means of judging and comparing the action of drugs thought to be effective in treating Raynaud's phenomenon. At present, cold tests exhibit poor reliability: The large number of tests proposed reflects the lack of agreement in this respect. Sensitivity, specificity and reproducibility fluctuate from one lab to another. It seems illusory to compare the diagnostic value of any cold test with that of clinical examination, for mathematical reasons, ie, the low prevalence of Raynaud's phenomenon in the general population (4%). At present, most of the positive results obtained in clinical trials of drugs which are effective in Raynaud's phenomenon are not correlated with the results of the cold tests.
血管反应性是一个血流动力学参数，难以量化，因为其可重复性通常不可预测。在人类临床实践中，寒冷是用于引发血管收缩的最常见应激因素。迫切需要进行冷试验以实现以下目的：一是作为研究血管疾病中冷反应性的生理学工具，二是作为判断和比较被认为对治疗雷诺现象有效的药物作用的客观手段。目前，冷试验的可靠性较差：大量提出的试验反映了在这方面缺乏共识。不同实验室之间，敏感性、特异性和可重复性存在波动。由于数学原因，即雷诺现象在普通人群中的低患病率（4%），将任何冷试验的诊断价值与临床检查的诊断价值进行比较似乎是不切实际的。目前，在治疗雷诺现象有效的药物临床试验中获得的大多数阳性结果与冷试验结果无关。
