Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, 4002 Basel, Switzerland.
J Natl Cancer Inst. 2011 Aug 17;103(16):1264-76. doi: 10.1093/jnci/djr244. Epub 2011 Jul 27.
It has been hypothesized that children and adolescents might be more vulnerable to possible health effects from mobile phone exposure than adults. We investigated whether mobile phone use is associated with brain tumor risk among children and adolescents.
CEFALO is a multicenter case-control study conducted in Denmark, Sweden, Norway, and Switzerland that includes all children and adolescents aged 7-19 years who were diagnosed with a brain tumor between 2004 and 2008. We conducted interviews, in person, with 352 case patients (participation rate: 83%) and 646 control subjects (participation rate: 71%) and their parents. Control subjects were randomly selected from population registries and matched by age, sex, and geographical region. We asked about mobile phone use and included mobile phone operator records when available. Odds ratios (ORs) for brain tumor risk and 95% confidence intervals (CIs) were calculated using conditional logistic regression models.
Regular users of mobile phones were not statistically significantly more likely to have been diagnosed with brain tumors compared with nonusers (OR = 1.36; 95% CI = 0.92 to 2.02). Children who started to use mobile phones at least 5 years ago were not at increased risk compared with those who had never regularly used mobile phones (OR = 1.26, 95% CI = 0.70 to 2.28). In a subset of study participants for whom operator recorded data were available, brain tumor risk was related to the time elapsed since the mobile phone subscription was started but not to amount of use. No increased risk of brain tumors was observed for brain areas receiving the highest amount of exposure.
The absence of an exposure-response relationship either in terms of the amount of mobile phone use or by localization of the brain tumor argues against a causal association.
有人假设，儿童和青少年可能比成年人更容易受到手机辐射的潜在健康影响。我们研究了手机使用是否与儿童和青少年脑肿瘤风险相关。
CEFALO 是一项在丹麦、瑞典、挪威和瑞士进行的多中心病例对照研究，包括 2004 年至 2008 年间诊断为脑肿瘤的所有 7-19 岁儿童和青少年。我们对 352 名病例患者（参与率：83%）和 646 名对照患者（参与率：71%）及其父母进行了面对面访谈，并随机从人口登记册中选择对照患者，并按年龄、性别和地理区域进行匹配。我们询问了移动电话的使用情况，并在可用时包括移动电话运营商的记录。使用条件逻辑回归模型计算了脑肿瘤风险的比值比（OR）和 95%置信区间（CI）。
与非使用者相比，经常使用手机的人被诊断患有脑肿瘤的可能性没有统计学意义（OR = 1.36；95% CI = 0.92-2.02）。与从未定期使用移动电话的人相比，至少 5 年前开始使用移动电话的儿童患脑肿瘤的风险没有增加（OR = 1.26，95% CI = 0.70-2.28）。在一部分可获得运营商记录数据的研究参与者中，脑肿瘤风险与移动电话订阅开始后的时间流逝有关，但与使用量无关。对于大脑接收最高暴露量的区域，未观察到脑肿瘤风险增加。
无论是在手机使用量方面还是在脑肿瘤定位方面，都没有暴露-反应关系，这表明两者之间没有因果关系。
