瘤内给药后磁性纳米颗粒的生物分布。
Magnetic nanoparticle biodistribution following intratumoral administration.
机构信息
Dartmouth Medical School and the Thayer School of Engineering, 8000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA.
出版信息
Nanotechnology. 2011 Aug 26;22(34):345101. doi: 10.1088/0957-4484/22/34/345101. Epub 2011 Jul 28.
Abstract
Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
摘要
最近，交变磁场（AMF）刺激下的氧化铁纳米粒子（IONPs）产生的热量在癌症治疗方面显示出了巨大的潜力。为了确定纳米颗粒诱导细胞毒性的机制，必须确定癌细胞与纳米颗粒的物理结合。我们已经使用透射电子显微镜（TEM）来定义体内给予的葡聚糖包覆的、具有 100-130nm 平均水动力直径的核壳结构 IONP 的细胞摄取，该 IONP 在一种鼠乳腺腺癌细胞系（MTG-B）中。肿瘤平均体积为 115mm3，并注射了氧化铁纳米粒子。然后在 IONP 注射后 0.1-120 小时切除肿瘤并进行 TEM 固定。IONP 注射后 1、2 和 4 小时的细胞内摄取分别为 5.0%、48.8%和 91.1%。这些信息对于有效利用 IONP 热疗治疗癌症是必不可少的。
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