Institute of Animal Husbandry Veterinary Sciences, Shanghai Academy of Agricultural Sciences, 2901 Beidi Road, Shanghai 201106, China.
Arch Virol. 2011 Nov;156(11):2045-52. doi: 10.1007/s00705-011-1064-2. Epub 2011 Jul 28.
A new rotavirus strain, sh0902, was detected in diarrheic piglets on a farm in Shanghai, China, and its genotype was characterized as G1P[7]. Analysis of the VP4, VP7 and NSP4 genes demonstrated VP4 homology to bovine and swine rotavirus strains; the nucleotide (nt) and amino acid (aa) identities were 99.7% and 99.5%, respectively. The VP7 gene was highly homologous to that of a giant panda rotavirus strain, with 98.5% similarity at the nt level and 99% similarity at the aa level. The nucleotide sequence of the NSP4 gene displayed high homology to human rotavirus strain R479, with 99.7% identity at the nt level and 99.3% identity at the aa level. This is the first report of an unusual porcine rotavirus strain with VP4, VP7 and NSP4 genes that are highly homologous to bovine, swine, giant panda and human strains isolated at geographically distant sites (South Korea, China and India). Our data indicate that rotaviruses have circulated among humans and animals and undergone genome reassortment.
在中国上海的一个农场中，从腹泻仔猪中检测到一株新的轮状病毒株 sh0902，其基因型被鉴定为 G1P[7]。对 VP4、VP7 和 NSP4 基因的分析表明，VP4 与牛和猪轮状病毒株具有同源性；核苷酸（nt）和氨基酸（aa）的同一性分别为 99.7%和 99.5%。VP7 基因与大熊猫轮状病毒株高度同源，nt 水平的相似性为 98.5%，aa 水平的相似性为 99%。NSP4 基因的核苷酸序列与人类轮状病毒株 R479 显示出高度同源性，nt 水平的同一性为 99.7%，aa 水平的同一性为 99.3%。这是首例报道的具有 VP4、VP7 和 NSP4 基因的不寻常猪轮状病毒株，这些基因与来自地理位置遥远的（韩国、中国和印度）的牛、猪、大熊猫和人类分离株具有高度同源性。我们的数据表明，轮状病毒在人类和动物中传播，并发生了基因组重配。
