University of Pernambuco, Recife, Pernambuco, Brazil.
J Alzheimers Dis. 2011;27(1):177-85. doi: 10.3233/JAD-2011-100915.
Dementia is a global public health problem and detection in the primary care setting, particularly in developing countries, is challenging. The aim of this research was to produce the cross-cultural validation of the AD8 interview to the Brazilian Portuguese Language. The original version of the AD8 was submitted to translation, back-translation, and application of the questionnaire to 20 elderly informants for face validation. The AD8-Brazil was then evaluated in 109 community-dwelling elderly with a sociodemographic questionnaire, clinical examination, Mini Mental State Examination (MMSE), Katz Inventory of Activities of Daily Living (ADL), and Clinical Dementia Rating scale (CDR). The AD8-Brazil was compared with the other instruments and with the clinical diagnosis (DSM-IV) for criterion validation. There was significant agreement of AD8-Brazil with diagnosis of dementia (p < 0.001), MMSE (p = 0.047), and ADL (PFisher = 0.004). Also, the AD8-Brazil was able to differentiate the stages of dementia by CDR scale. The reliability was high (alpha = 0.818) and reproducibility analysis showed excellent inter-rater (kappa = 0.889) and test-retest consistency (kappa = 0.814). The AD8-Brazil showed excellent discrimination between CDR 0 and CDR > 0 (area under the curve 86.1%) and between CDR 0 and CDR 0.5 (area under the curve 76.9%). The administration of the questionnaire took 2.3 ± 0.1 minutes. The Brazilian version of the AD8 is a valid, reliable, quick, and easy screening instrument for dementia.
痴呆是一个全球性的公共卫生问题，在初级保健环境中进行检测，尤其是在发展中国家，具有挑战性。本研究的目的是为巴西葡萄牙语版 AD8 访谈进行跨文化验证。原始版本的 AD8 经过翻译、回译和问卷调查，对 20 名老年受访者进行了面对面验证。然后，AD8-Brazil 在 109 名居住在社区的老年人中进行了评估，使用社会人口学问卷、临床检查、简易精神状态检查（MMSE）、Katz 日常生活活动量表（ADL）和临床痴呆评定量表（CDR）。AD8-Brazil 与其他工具和临床诊断（DSM-IV）进行了比较，以进行标准验证。AD8-Brazil 与痴呆诊断（p < 0.001）、MMSE（p = 0.047）和 ADL（PFisher = 0.004）的一致性显著。此外，AD8-Brazil 还可以通过 CDR 量表区分痴呆的阶段。信度高（alpha = 0.818），重测分析显示良好的组内一致性（kappa = 0.889）和测试-重测一致性（kappa = 0.814）。AD8-Brazil 在 CDR 0 与 CDR > 0（曲线下面积 86.1%）和 CDR 0 与 CDR 0.5（曲线下面积 76.9%）之间具有出色的区分能力。问卷的管理时间为 2.3 ± 0.1 分钟。巴西版 AD8 是一种有效、可靠、快速且易于使用的痴呆筛查工具。
