Li Tao, Wang Hua-li, Yang Yuan-han, Galvin James E, Morris John C, Yu Xin
Peking University Institute of Mental Health, Key Laboratory for Mental Health, Ministry of Health, Beijing 100191, China.
Zhonghua Nei Ke Za Zhi. 2012 Oct;51(10):777-80.
To examine the validity and reliability of the application of Chinese version of AD8 among patients with Alzheimer's disease (AD), and to explore the discriminative properties of AD8 including score boundaries, sensitivity and specificity in differentiating AD and normal controls.
A total of 240 subjects were recruited, including 75 cognitively intact subjects as normal control and 165 patients with AD. Normal control and patients with AD were assessed with Clinical Dementia Rating (CDR), Mini-Mental State Examination (MMSE), and Clock Drawing Test (CDT). All informed normal controls and informants of patients with AD were asked about Chinese version of AD8, among which, 158 informants of patients with AD received AD8 examination again.
(1) The Cronbach alpha for Chinese version of AD8 was 0.78. The intraclass correlation coefficient (ICC) of retest reliability was 0.96 (P < 0.01). (2) The correlation coefficients between each item of AD8 ranged from 0.36 to 0.69 (P < 0.01). Chinese version of AD8 total scores were strongly positively correlated with CDR global score (r = 0.82, P < 0.01), and CDR-SB(r = 0.80, P < 0.01), and negatively correlated with the total score of MMSE (r = -0.75, P < 0.01) and CDT (r = -0.53, P < 0.01). (3) For discrimination between normal controls and patients with AD, the AUC was 0.93. Using a cutoff of 2 or greater on Chinese version of AD8 to discriminate dementia, the sensitivity was 93.9%, and specificity was 76.0%.
Chinese version of AD8 is a brief and sensitive screening measure with good validity and reliability.
检验中文版AD8在阿尔茨海默病（AD）患者中的有效性和可靠性，并探讨AD8在区分AD患者与正常对照方面的判别特性，包括得分界限、敏感性和特异性。
共招募240名受试者，其中75名认知功能正常的受试者作为正常对照，165名AD患者。正常对照和AD患者接受了临床痴呆评定量表（CDR）、简易精神状态检查表（MMSE）和画钟试验（CDT）评估。所有知情的正常对照和AD患者的 informant 均被问及中文版AD8，其中，158名AD患者的 informant 再次接受了AD8检查。
（1）中文版AD8的Cronbach α系数为0.78。重测信度的组内相关系数（ICC）为0.96（P<0.01）。（2）AD8各条目之间的相关系数在0.36至0.69之间（P<0.01）。中文版AD8总分与CDR整体评分（r = 0.82，P<0.01）、CDR-SB（r = 0.80，P<0.01）呈强正相关，与MMSE总分（r = -0.75，P<0.01）和CDT（r = -0.53，P<0.01）呈负相关。（3）在区分正常对照和AD患者方面，曲线下面积（AUC）为0.93。采用中文版AD8得分2分及以上来鉴别痴呆，敏感性为93.9%，特异性为76.0%。
中文版AD8是一种简短且敏感的筛查工具，具有良好的有效性和可靠性。
