Dominguez Jacqueline C, de Guzman Ma Fe P, Joson Ma Lourdes C, Fowler Krizelle, Natividad Boots P, Cruz Precy S, Jiloca Jose Leo, Mactal Primitivo B, Dominguez Jayvee Dyne, Domingo Jeffrey, Dominguez-Awao Jhozel Kim, Reandelar Macario, Javier Jem R, Phung ThienKieuThi, Morris John C, Galvin James E
Institute for Neurosciences, St. Luke's Medical Center, Quezon City 1102, Philippines.
Institute for Dementia Care Asia, Quezon City 1102, Philippines.
Int J Alzheimers Dis. 2021 Oct 31;2021:7750235. doi: 10.1155/2021/7750235. eCollection 2021.
This study was aimed at validating the Filipino version of AD8 (AD8-P).
Community-dwelling Filipino older persons aged ≥60 years, together with their informants, participated in this study. Psychologists independently interviewed the informants with AD8-P and administered the Filipino-validated Mini-Mental State Examination (MMSE-P) and Montreal Cognitive Assessment (MoCA-P) to the older persons. Neurologists and geriatrician conducted physical and neurological examination and Clinical Dementia Rating™ (CDR™) to determine cognitive diagnosis and were blinded with the results of AD8-P. Dementia was diagnosed based on DSM-IV-TR criteria. AD8-P discriminatory ability to screen for dementia was evaluated according to DSM-IV-TR diagnostic criteria for dementia.
A total of 366 community-dwelling Filipino older persons aged ≥60 years, 213 with normal cognition and 153 with dementia, and their informants were included in this study. Majority (90%) were at the mildest stage of dementia. Area under the receiver-operating-characteristic curve (AUROC) for AD8-P was 0.94 (95% CI 0.92 to 0.96), demonstrating excellent overall predictive power to screen for dementia. The optimal AD8-P cut-off score with best balance sensitivity (91.5%) and specificity (77.9%) was ≥3.
AD8-P demonstrated good psychometric properties to screen for dementia, even at the earliest stage of cognitive decline.
本研究旨在验证AD8的菲律宾语版本（AD8-P）。
年龄≥60岁的菲律宾社区居住老年人及其 informant 参与了本研究。心理学家独立使用AD8-P对 informant 进行访谈，并对老年人进行经过菲律宾语验证的简易精神状态检查表（MMSE-P）和蒙特利尔认知评估（MoCA-P）。神经科医生和老年病科医生进行体格和神经学检查以及临床痴呆评定量表（CDR™）以确定认知诊断，且对AD8-P的结果不知情。根据《精神疾病诊断与统计手册第四版，修订版》（DSM-IV-TR）标准诊断痴呆。根据DSM-IV-TR痴呆诊断标准评估AD8-P筛查痴呆的鉴别能力。
本研究纳入了总共366名年龄≥60岁的菲律宾社区居住老年人、213名认知正常者和153名痴呆患者及其 informant。大多数（90%）处于痴呆最轻微阶段。AD8-P的受试者工作特征曲线下面积（AUROC）为0.94（95%CI 0.92至0.96），表明其筛查痴呆具有出色的总体预测能力。平衡灵敏度（91.5%）和特异性（77.9%）最佳的AD8-P最佳截断分数为≥3。
AD8-P在筛查痴呆方面表现出良好的心理测量特性，即使在认知衰退的最早阶段也是如此。
