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本文引用的文献

1
Tuning the formation and degradation of layer-by-layer assembled polymer hydrogel microcapsules.调控层层组装聚合物水凝胶微胶囊的形成和降解。
Langmuir. 2009 Dec 15;25(24):14079-85. doi: 10.1021/la901687a.
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Polymer-lipid microbubbles for biosensing and the formation of porous structures.聚合物-脂质微泡用于生物传感和多孔结构的形成。
J Colloid Interface Sci. 2010 Apr 15;344(2):521-7. doi: 10.1016/j.jcis.2010.01.042. Epub 2010 Jan 18.
3
New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: Part I--Formulation development and in-vitro characterization.新型载多柔比星磷脂微泡靶向肿瘤治疗的研究：第一部分——制剂的制备及体外性质考察。
J Control Release. 2010 Apr 2;143(1):143-50. doi: 10.1016/j.jconrel.2009.12.026. Epub 2010 Jan 11.
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Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved.载多柔比星微泡的设计与评价及其超声触发释药的细胞毒性和作用机制
Mol Ther. 2010 Jan;18(1):101-8. doi: 10.1038/mt.2009.160. Epub 2009 Jul 21.
5
Lipid-shelled vehicles: engineering for ultrasound molecular imaging and drug delivery.脂质壳型载体：用于超声分子成像和药物递送的工程设计
Acc Chem Res. 2009 Jul 21;42(7):881-92. doi: 10.1021/ar8002442.
6
Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy.用于靶向治疗的多相载药脂质球的可控微流体制备
Biotechnol Prog. 2009 Jul-Aug;25(4):938-45. doi: 10.1002/btpr.214.
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Microbubbles in ultrasound-triggered drug and gene delivery.超声触发药物和基因递送中的微泡
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Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging.定制超声造影剂的尺寸分布：提高分子成像灵敏度的可能方法。
Mol Imaging. 2007 Nov-Dec;6(6):384-92.
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Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery.超声微泡造影剂：基本原理及其在基因和药物递送中的应用
Annu Rev Biomed Eng. 2007;9:415-47. doi: 10.1146/annurev.bioeng.8.061505.095852.
10
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound.使用磁共振成像（MRI）引导的聚焦超声将阿霉素以治疗水平靶向递送至大鼠脑部。
Int J Cancer. 2007 Aug 15;121(4):901-7. doi: 10.1002/ijc.22732.

简便的一锅法合成具有增强载药能力的聚合物-磷脂复合微泡用于超声触发治疗

Facile One-Pot Synthesis of Polymer-Phospholipid Composite Microbubbles with Enhanced Drug Loading Capacity for Ultrasound-Triggered Therapy.

作者信息

Nakatsuka Matthew A, Lee Joo Hye, Nakayama Emi, Hung Albert M, Hsu Mark J, Mattrey Robert F, Esener Sadik C, Cha Jennifer N, Goodwin Andrew P

机构信息

University of California, San Diego, Department of Nanoengineering, 9500 Gilman Dr. #0048, La Jolla, CA 92093, USA.

出版信息

Soft Matter. 2011;2011(7):1656-1659. doi: 10.1039/C0SM01131B.

DOI:10.1039/C0SM01131B
PMID:21799701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3143006/
Abstract

This paper reports the one-pot synthesis of perfluorocarbon microbubbles with crosslinked shells of poly(acrylic acid) and phospholipid that boast excellent ultrasound contrast enhancement, enhanced loading capacity, and the ability to retain or release their contents through variation in the level of ultrasound exposure.

摘要

本文报道了一种全氟化碳微泡的一锅法合成，其具有由聚丙烯酸和磷脂构成的交联壳层，具备优异的超声造影增强效果、更高的负载能力，以及能够通过改变超声暴露水平来保留或释放其内容物的能力。