Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093-0448, USA.
Adv Mater. 2012 Nov 27;24(45):6010-6. doi: 10.1002/adma.201201484. Epub 2012 Sep 3.
Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.
血栓形成,或恶性血液凝结,与许多心血管疾病和癌症有关。本文提出了一种微泡造影剂,只有在暴露于升高的凝血酶水平时才会产生超声谐波信号。最初沉默的微泡在存在凝血酶和新鲜凝血的情况下在三分钟内被激活,检测限为 20 nM 凝血酶和 2 aM 微泡。