Zhu Yingdong, Zhang Ping, Yu Haiping, Li Jia, Wang Ming-Wei, Zhao Weimin
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
J Nat Prod. 2007 Oct;70(10):1570-7. doi: 10.1021/np070260v. Epub 2007 Sep 21.
Chemical studies on the constituents of Dracaena cochinchinensis led to the discovery of eight new flavonoid derivatives ( 1- 8) along with 14 known compounds ( 9- 22). The identification and structural elucidation of these isolates were based on spectral analyses. All isolates were tested for antibacterial activities against Helicobacter pylori (ATCC43504) and thrombin inhibitory effects. As a result, new flavonoid derivatives 6 and 7 and (2 S)-4',7-dihydroxy-8-methylflavan ( 11) were found to be most efficacious against H. pylori (ATCC43504) with MIC values of 29.5, 29.5, and 31.3 microM, respectively, and the seven new flavonoid derivatives ( 1- 7) and one known biflavonoid ( 9) were observed to exhibit moderate thrombin inhibitory activity.
对柬埔寨龙血树成分的化学研究导致发现了8种新的黄酮类衍生物（1 - 8）以及14种已知化合物（9 - 22）。这些分离物的鉴定和结构解析基于光谱分析。所有分离物均针对幽门螺杆菌（ATCC43504）进行了抗菌活性测试以及凝血酶抑制作用测试。结果发现，新的黄酮类衍生物6和7以及（2S）-4',7-二羟基-8-甲基黄烷（11）对幽门螺杆菌（ATCC43504）最有效，其MIC值分别为29.5、29.5和31.3微摩尔，并且观察到7种新的黄酮类衍生物（1 - 7）和1种已知的双黄酮（9）表现出适度的凝血酶抑制活性。
