Childress Michael O, Adams Larry G, Ramos-Vara José A, Freeman Lynetta J, He Shuang, Constable Peter D, Knapp Deborah W
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
J Am Vet Med Assoc. 2011 Aug 1;239(3):350-6. doi: 10.2460/javma.239.3.350.
To assess the diagnostic utility of transurethral cystoscopic biopsy in dogs with histologically confirmed transitional cell carcinoma (TCC) of the urinary bladder and urethra.
Retrospective case series.
92 dogs with histologically confirmed TCC.
Information on sex, breed, neuter status, body weight, tumor location, biopsy method, number of biopsy procedures, experience level of clinician performing biopsy, and quality of biopsy sample was obtained from medical records. The association of variables with likelihood of achieving a diagnostic-quality biopsy sample was evaluated by use of logistic regression.
If used as the initial biopsy method, cystoscopic biopsy samples were of diagnostic quality in 65% of male dogs and 96% of female dogs with histologically confirmed TCC. Cystoscopic biopsy samples were significantly more likely to be of diagnostic quality in female dogs than in male dogs.
Cystoscopic biopsy is an effective method to obtain biopsy samples in dogs with TCC of the bladder and urethra. Cystoscopy is more likely to produce a diagnostic-quality biopsy sample in female dogs with TCC than in male dogs with TCC. Cystoscopy should be considered as a primary means of biopsy in male and female dogs with masses of the urinary bladder or urethra.
评估经尿道膀胱镜活检在组织学确诊为膀胱和尿道移行细胞癌（TCC）的犬中的诊断效用。
回顾性病例系列。
92只组织学确诊为TCC的犬。
从病历中获取有关性别、品种、绝育状态、体重、肿瘤位置、活检方法、活检程序数量、进行活检的临床医生经验水平以及活检样本质量的信息。使用逻辑回归评估变量与获得诊断质量活检样本可能性之间的关联。
如果用作初始活检方法，膀胱镜活检样本在65%的组织学确诊为TCC的雄性犬和96%的雌性犬中具有诊断质量。膀胱镜活检样本在雌性犬中具有诊断质量的可能性显著高于雄性犬。
膀胱镜活检是获取膀胱和尿道TCC犬活检样本的有效方法。膀胱镜检查在患有TCC的雌性犬中比在患有TCC的雄性犬中更有可能产生具有诊断质量的活检样本。对于患有膀胱或尿道肿块的雄性和雌性犬，膀胱镜检查应被视为活检的主要手段。
